Viral vector-mediated blockade of the endocrine stress-response modulates non-spatial memory

Deveroux Ferguson, Sophia Lin, Robert Sapolsky

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Stress results in the release of glucocorticoids (GCs) which at high levels, impair performance on hippocampus-dependent tasks. Estrogen is neurotrophic and can rescue stress-induced memory impairments. Here we report the use of a viral vector to overexpress a chimeric gene (ER/GR) that converts the deleterious effects of glucocorticoids into beneficial estrogenic effects. A short immobilization stress regimen was sufficient to impair non-spatial memory. In contrast, viral vector-mediated overexpression of ER/GR in the dentate gyrus of the hippocampus protected against stress-induced impairments of non-spatial memory. These data add to the growing evidence that increasing estrogenic signaling can protect against the impairing effects of stress on non-spatial memory.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalNeuroscience Letters
Volume437
Issue number1
DOIs
StatePublished - May 23 2008
Externally publishedYes

Keywords

  • Cognition
  • Estrogen
  • Gene therapy
  • Memory
  • Non-spatial memory
  • Stress

ASJC Scopus subject areas

  • Neuroscience(all)

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