Vitamin B6: Beyond coenzyme functions

Georg T. Wondrak, Elaine L. Jacobson

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Endogenous reactive intermediates such as photoexcited states of tissue chromophores, reactive oxygen species (ROS), reactive carbonyl species (RCS), and transition metal ions are mediators of tissue damage involved in initiation and progression of human pathologies including tumorigenesis, atherosclerosis, diabetes, and neurodegenerative disease. A large body of evidence now suggests that B6 vitamers antagonize the harmful activity of endogenous reactive intermediates fulfilling a very different role than that established as a cofactor for numerous enzymes. In this chapter, the structural basis of vitamin B6 activity as a potent antioxidant, metal chelator, carbonyl scavenger, and photosensitizer is presented and the physiological relevance is discussed.

Original languageEnglish (US)
Pages (from-to)291-300
Number of pages10
JournalSub-cellular biochemistry
Volume56
DOIs
StatePublished - Jan 1 2012

Keywords

  • Atherosclerosis
  • Carbonyl scavenger
  • Diabetes
  • Glycation
  • Metal chelator
  • Ntioxidant
  • Vitamin B6

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology
  • Cancer Research

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