Vitamin B6

Vanessa R. Da Silva, Katelyn A. Russell, Jesse F. Gregory

Research output: Chapter in Book/Report/Conference proceedingChapter

11 Citations (Scopus)

Abstract

Vitamin B 6 is a family of related compounds comprised of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), along with their phosphate esters and glucosides. The primary vitamin B 6 coenzymic form, pyridoxal 5 '-phosphate, is an obligatory cofactor in over 140 enzymatic reactions primarily in the metabolism of amino acids but also in reactions of carbohydrates and lipids. Vitamin B 6 also plays a vital role in one-carbon metabolism, facilitating cellular methylation processes, methionine recycling, regulation of homocysteine, and synthesis of cysteine. Recent findings indicate that marginal vitamin B 6 status remains a concern in human nutrition, at least in segments of the population. The consequence of marginal vitamin B 6 status is unclear but serves as cause for concern in view of associations between low vitamin B 6 status, risk of cardiovascular disease and stroke, and certain cancers. This chapter provides an overview of vitamin B 6 bioavailability, metabolism and metabolic function, nutritional status and assessment, and roles in human health and disease.

Original languageEnglish (US)
Title of host publicationPresent Knowledge in Nutrition
Subtitle of host publicationTenth Edition
PublisherWiley-Blackwell
Pages307-320
Number of pages14
ISBN (Print)9780470959176
DOIs
StatePublished - Jun 18 2012
Externally publishedYes

Fingerprint

Vitamin B 6
Pyridoxamine
Pyridoxal
Pyridoxine
Nutrition Assessment
Pyridoxal Phosphate
Glucosides
Recycling
Homocysteine
Nutritional Status
Methionine
Methylation
Biological Availability
Cysteine
Esters
Cardiovascular Diseases
Carbon
Phosphates
Myocardial Infarction
Carbohydrates

Keywords

  • Chronic, vitamin B6 nutrition status and aberrant one-carbon metabolism
  • Genetic and nutritional factors in health and disease susceptibility
  • Marginal vitamin B6 status, concerns in human nutrition, of populations
  • PLP metabolism and vitamin B6 deficiency, adverse effects
  • PLP-dependent and one-carbon metabolism, in folate, methionine cycle
  • PLP-dependent, direct/indirect in metabolic phases
  • Vitamin B6 disposition and metabolic function
  • Vitamin B6 metabolism and role as a coenzyme
  • Vitamin B6, a family of related compounds of PN, PL, and PM
  • Vitamin B6, in foods of plant and animal origin

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Da Silva, V. R., Russell, K. A., & Gregory, J. F. (2012). Vitamin B6. In Present Knowledge in Nutrition: Tenth Edition (pp. 307-320). Wiley-Blackwell. https://doi.org/10.1002/9781119946045.ch20

Vitamin B6. / Da Silva, Vanessa R.; Russell, Katelyn A.; Gregory, Jesse F.

Present Knowledge in Nutrition: Tenth Edition. Wiley-Blackwell, 2012. p. 307-320.

Research output: Chapter in Book/Report/Conference proceedingChapter

Da Silva, VR, Russell, KA & Gregory, JF 2012, Vitamin B6. in Present Knowledge in Nutrition: Tenth Edition. Wiley-Blackwell, pp. 307-320. https://doi.org/10.1002/9781119946045.ch20
Da Silva VR, Russell KA, Gregory JF. Vitamin B6. In Present Knowledge in Nutrition: Tenth Edition. Wiley-Blackwell. 2012. p. 307-320 https://doi.org/10.1002/9781119946045.ch20
Da Silva, Vanessa R. ; Russell, Katelyn A. ; Gregory, Jesse F. / Vitamin B6. Present Knowledge in Nutrition: Tenth Edition. Wiley-Blackwell, 2012. pp. 307-320
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