Vitamin c for cardiac protection during percutaneous coronary intervention: A systematic review of randomized controlled trials

Sher Ali Khan, Sandipan Bhattacharjee, Muhammad Owais Abdul Ghani, Rachel Walden, Qin M. Chen

Research output: Contribution to journalReview article

Abstract

Percutaneous coronary intervention (PCI) is the preferred treatment for acute coronary syndrome (ACS) secondary to atherosclerotic coronary artery disease. This nonsurgical procedure is also used for selective patients with stable angina. Although the procedure is essential for restoring blood flow, reperfusion can increase oxidative stress as a side effect. We address whether intravenous infusion of vitamin C (VC) prior to PCI provides a benefit for cardioprotection. A total of eight randomized controlled trials (RCT) reported in the literature were selected from 371 publications through systematic literature searches in six electronic databases. The data of VC effect on cardiac injury biomarkers and cardiac function were extracted from these trials adding up to a total of 1185 patients. VC administration reduced cardiac injury as measured by troponin and CK-MB elevations, along with increased antioxidant reservoir, reduced reactive oxygen species (ROS) and decreased inflammatory markers. Improvement of the left ventricular ejection fraction (LVEF) and telediastolic left ventricular volume (TLVV) showed a trend but inconclusive association with VC. Intravenous infusion of VC before PCI may serve as an effective method for cardioprotection against reperfusion injury.

Original languageEnglish (US)
Article number2199
Pages (from-to)1-21
Number of pages21
JournalNutrients
Volume12
Issue number8
DOIs
StatePublished - Aug 2020

Keywords

  • CK-MB
  • Left ventricular ejection fraction (LVEF)
  • Periprocedural myocardial injury (PMI)
  • Reactive oxygen species (ROS)
  • Troponin
  • Vitamin C (VC)

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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