Vitamin D and immune response: Implications for prostate cancer in African Americans

Ken Batai, Adam B. Murphy, Larisa Nonn, Rick A Kittles

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Prostate cancer (PCa) is the most common cancer among men in the U.S. African American (AA) men have a higher incidence and mortality rate compared to European American (EA) men, but the cause of PCa disparities is still unclear. Epidemiologic studies have shown that vitamin D deficiency is associated with advanced stage and higher tumor grade and mortality, while its association with overall PCa risk is inconsistent. Vitamin D deficiency is also more common in AAs than EAs, and the difference in serum vitamin D levels may help explain the PCa disparities. However, the role of vitamin D in aggressive PCa in AAs is not well explored. Studies demonstrated that the active form of vitamin D, 1,25-dihydroxyvitamin D, has anti-inflammatory effects by mediating immune-related gene expression in prostate tissue. Inflammation also plays an important role in PCa pathogenesis and progression, and expression of immune-related genes in PCa tissues differs significantly between AAs and EAs. Unfortunately, the evidence linking vitamin D and immune response in relation to PCa is still scarce. This relationship should be further explored at a genomic level in AA populations that are at high risk for vitamin D deficiency and fatal PCa.

Original languageEnglish (US)
Article number53
JournalFrontiers in Immunology
Volume7
Issue numberFEB
DOIs
StatePublished - 2016

Keywords

  • African Americans
  • Health disparities
  • Inflammation
  • Prostate cancer
  • Vitamin D

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Fingerprint Dive into the research topics of 'Vitamin D and immune response: Implications for prostate cancer in African Americans'. Together they form a unique fingerprint.

  • Cite this