Vitamin D: Biochemistry and clinical applications

Michael J. Pitt, Mark R Haussler

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Major advances in the field of vitamin D metabolism have been achieved in the past decade that have considerably enhanced our understanding of a variety of metabolic bone diseases which include the rachitic and osteomalacic syndromes and parathyroid gland disorders. Delineation of the biochemical structure, metabolic pathways, mechanisms regulating synthesis, and physiologic functions has established that the compound should more appropriately be considered a hormone. Obligatory sequential, two-step hydroxylation of the prohormone, vitamin D, is necessary before physiologic action occurs. Initial hydroxylation occurs mainly in the liver while the second hydroxylation occurs exclusively in the kidney. The physiologically active form of the hormone, 1,25-(OH)<inf>2</inf>-D, coordinates with parathyroid hormone (and probably calcitonin) in promoting homeostasis of both extra-cellular calcium and phosphorus and the skeletal system. This article reviews the basic metabolism of vitamin D, the modes of physiologic action, the endocrine features of vitamin D and its relationship to parathyroid hormone, and discusses the important medical applications of this information.

Original languageEnglish (US)
Pages (from-to)191-208
Number of pages18
JournalSkeletal Radiology
Volume1
Issue number4
DOIs
StatePublished - 1977

Fingerprint

Vitamin D
Biochemistry
Hydroxylation
Parathyroid Hormone
Parathyroid Diseases
Hormones
Rickets
Parathyroid Glands
Metabolic Bone Diseases
Calcitonin
Metabolic Networks and Pathways
Phosphorus
Homeostasis
Calcium
Kidney
Liver

Keywords

  • Calcium
  • Osteomalacia
  • Parathyroid hormone
  • Phosphorus
  • Rickets
  • Skeleton
  • Vitamin D

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Vitamin D : Biochemistry and clinical applications. / Pitt, Michael J.; Haussler, Mark R.

In: Skeletal Radiology, Vol. 1, No. 4, 1977, p. 191-208.

Research output: Contribution to journalArticle

Pitt, Michael J. ; Haussler, Mark R. / Vitamin D : Biochemistry and clinical applications. In: Skeletal Radiology. 1977 ; Vol. 1, No. 4. pp. 191-208.
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