Vitamin D Nutrient-Gene Interactions and Healthful Aging

Mark R Haussler, Rimpi K. Saini, Marya S. Sabir, Christopher M. Dussik, Zainab Khan, G Kerr Whitfield, Kristin P. Griffin, Ichiro Kaneko, Peter W. Jurutka

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

1,25-Dihydroxyvitamin D3 (1,25D) is the endocrine metabolite of vitamin D that signals through binding to the vitamin D receptor (VDR). The ligand-receptor complex transcriptionally regulates genes that encode factors promoting intestinal calcium and phosphate absorption plus bone remodeling, maintaining a skeleton with reduced risk of age-related osteoporotic fractures. 1,25D/VDR signaling further exerts feedback control of mineral ions via regulation of FGF23, klotho, and CYP24A1 to prevent age-related, ectopic calcification, and associated pathologies. Vitamin D also elicits xenobiotic detoxification, oxidative stress reduction, antimicrobial defense, immunoregulation, anti-inflammatory/anticancer actions, and cardiovascular benefits. 1,25D exerts neuroprotective actions against excitotoxicity, and induces serotonin mood elevator to support cognitive function and prosocial behavior. Nutrient, low-affinity VDR ligands including curcumin, polyunsaturated fatty acids, and delphinidin/anthocyanidins initiate VDR signaling, whereas longevity agents such as resveratrol and SIRT1 potentiate VDR signaling. Therefore, liganded VDR modulates the expression of a network of genes that facilitates health span by delaying the chronic diseases of aging.

Original languageEnglish (US)
Title of host publicationMolecular Basis of Nutrition and Aging: A Volume in the Molecular Nutrition Series
PublisherElsevier Inc.
Pages449-471
Number of pages23
ISBN (Electronic)9780128018279
ISBN (Print)9780128018163
DOIs
StatePublished - Apr 28 2016

Keywords

  • 1,25-Dihydroxyvitamin D
  • Anti-inflammatory
  • Anticancer nutrient
  • Ectopic calcification
  • FGF23
  • Klotho
  • Neuroprotection
  • Osteoporosis
  • Vitamin D receptor

ASJC Scopus subject areas

  • Medicine(all)

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    Haussler, M. R., Saini, R. K., Sabir, M. S., Dussik, C. M., Khan, Z., Whitfield, G. K., Griffin, K. P., Kaneko, I., & Jurutka, P. W. (2016). Vitamin D Nutrient-Gene Interactions and Healthful Aging. In Molecular Basis of Nutrition and Aging: A Volume in the Molecular Nutrition Series (pp. 449-471). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-801816-3.00033-9