Vitamin E attenuates myocardial ischemia-reperfusion injury in murine AIDS

Yinhong Chen, Grace Davis-Gorman, Ronald R Watson, Paul F. McDonagh

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The incidence of myocardial infarction in patients who have the aquired immunodeficiency syndrome (AIDS) is increasing. However, no effective therapeutic agents have been discovered to reduce myocardial ischemia-reperfusion (I/R) injury in pathologies associated with AIDS. The aim of this study was to determine if infarct size is increased in murine AIDS after I/R injury and if I/R injury could be attenuated with vitamin E supplementation. Three groups of mice were studied: control, murine AIDS, and murine AIDS with vitamin E supplementation. Anesthetized mice were subjected to 30 min of left anterior descending coronary artery occlusion and 120 min of reperfusion. The hearts in mice that had murine AIDS had a larger infarct size compared to controls after I/R injury. Vitamin E supplementation significantly reduced infarct size and inhibited polymorphonuclear neutrophil (PMN) CD11b expression (p < 0.05). However, vitamin E supplementation did not affect PMN reactive oxygen species (ROS) production and platelet CD62p expression. These results suggest that the reduction of myocardial I/R injury with vitamin E supplementation may be the result of the inhibition of PMN CD11b expression. Vitamin E may be a promising prophylactic agent for the reduction of the severity of myocardial I/R injury in patients who have AIDS.

Original languageEnglish (US)
Pages (from-to)119-127
Number of pages9
JournalCardiovascular Toxicology
Volume2
Issue number2
DOIs
Publication statusPublished - 2002

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Keywords

  • Ischemia-reperfusion injury
  • Murine AIDS
  • Vitamin E

ASJC Scopus subject areas

  • Toxicology
  • Cardiology and Cardiovascular Medicine

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