Vitamin E supplementation prevents lung dysfunction and lipid peroxidation in nude mice exposed to side-stream cigarette smoke

Zhen Zhang, Mohsen Araghiniknam, Paula Inserra, Shuguang Jiang, Jeongmin Lee, Sherry Chow, Veronica Breceda, Madel Balagtas, Mark Witten, Ronald R. Watson

Research output: Contribution to journalArticle

8 Scopus citations


Sidestream cigarette smoke (SSCS) is a major component of environmental tobacco smoke. The purpose of this study was to investigate development of lung injury and lipid peroxidation in the lung and liver of immunodeficient (Nude) mice exposed to a small amount of SSCS (a total 5 hours of exposure). The effects of vitamin E supplementation of the mice were also determined. SSCS increased pulmonary resistance and lipid peroxidation in these mice. Dietary vitamin E supplementation increased vitamin E levels in lung and liver. In addition, vitamin E attenuated SSCS-mediated pulmonary injury and lipid peroxidation. It appears that the enhanced resistance against SSCS- induced lung injury and lipid peroxidation may be primarily due to the increased antioxidant property of vitamin E in vitamin E-supplemented mice.

Original languageEnglish (US)
Pages (from-to)75-84
Number of pages10
JournalNutrition Research
Issue number1
StatePublished - Jan 1 1999



  • Lipid peroxidation
  • Lung function
  • Nude mice
  • Sidestream cigarette smoke (SSCS)
  • Tobacco smoke
  • Vitamin E

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

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