Vitamin E supplementation with interferon-γ administration retards immune dysfunction during murine retrovirus infection

J. Y. Wang, B. Liang, Ronald R Watson

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Murine retrovirus infection induces loss of vitamin E and immune dysfunction with loss of cytokine production by T-helper cells. Therefore interferon-γ (IFN-γ) was given during dietary vitamin E supplementation to effectively prevent murine retrovirus-induced immunosuppression, cytokine dysregulation, and development of murine AIDS. Administration of IFN-γ during vitamin E supplementation significantly prevented development of retrovirus-induced suppression of splenic natural killer cell activity and T cell proliferation. It also significantly slowed retrovirus-induced elevation of T helper (Th) 2 cytokine [interleukin (IL)-4, IL-5, and IL-10] production and monokine (IL-6 and tumor necrosis factor-α) secretion by splenocytes. The treatment also prevented loss of Th1 cytokine (IL-2 and IFN-γ) secretion by splenocytes from retrovirus-infected mice alleviating splenomegaly and hypergammaglobulinemia. The combined therapy had an additive therapeutic impact. It was more effective than IFN-γ treatment or vitamin E supplementation alone in delaying the development of retrovirus-induced immunosuppression with its cytokine dysregulation.

Original languageEnglish (US)
Pages (from-to)698-703
Number of pages6
JournalJournal of Leukocyte Biology
Volume58
Issue number6
StatePublished - 1995

Fingerprint

Retroviridae Infections
Retroviridae
Vitamin E
Interferons
Cytokines
Immunosuppression
Murine Acquired Immunodeficiency Syndrome
Monokines
Hypergammaglobulinemia
Splenomegaly
Interleukin-5
Therapeutics
Helper-Inducer T-Lymphocytes
Natural Killer Cells
Interleukin-4
Interleukin-10
Interleukin-2
Interleukin-6
Tumor Necrosis Factor-alpha
Cell Proliferation

Keywords

  • Cytokine
  • Immune response
  • Murine AIDS

ASJC Scopus subject areas

  • Cell Biology

Cite this

Vitamin E supplementation with interferon-γ administration retards immune dysfunction during murine retrovirus infection. / Wang, J. Y.; Liang, B.; Watson, Ronald R.

In: Journal of Leukocyte Biology, Vol. 58, No. 6, 1995, p. 698-703.

Research output: Contribution to journalArticle

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