Vitamins and immunomodulation in AIDS

Bailin Liang, Sangbun Chung, Moshen Araghiniknam, Lisa C. Lane, Ronald R Watson

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Acquired immune deficiency syndrome (AIDS) is a clinical disorder caused by a retrovirus infection and represents the end point in a progressive sequence of immunosuppressive changes. Vitamins can enhance disease resistance in animals and humans. As such they are important co-factors in optimal functioning of the immune systems. In this article, the immunological and nutritional modifications caused by AIDS are summarized. The effects of murine and human retrovirus infection on vitamin status are analyzed as co- factors in the development of severe immune dysfunction, AIDS. The properties of immunoenhancing antioxidative vitamins, vitamin A, B6, B12, C, E, and β-carotene, which are frequently low in AIDS patients, are evaluated relative to the development of immunodeficiency during retrovirus infection. Vitamin A, E, and B12 deficiency accelerated the development of AIDS with low T cells, whereas their normalization retarded the development of immune dysfunction. The interactions between these vitamins and the immune system in human AIDS patients and animal models of AIDS are reviewed. Our purpose is to provide data on how retrovirus infection can cause nutritional deficiencies that accentuate immune damage and to evaluate the potential therapeutic role of vitamins in the treatment of immune dysfunctions in AIDS patients.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalNutrition
Volume12
Issue number1
DOIs
StatePublished - 1996

Fingerprint

Immunomodulation
Vitamins
Acquired Immunodeficiency Syndrome
Retroviridae Infections
Immune System
Vitamin E Deficiency
Vitamin B 12 Deficiency
Vitamin A Deficiency
Vitamin B 6
Disease Resistance
Carotenoids
Immunosuppressive Agents
Vitamin A
Malnutrition
Animal Models
T-Lymphocytes
Therapeutics

Keywords

  • AIDS
  • disease resistance
  • immunoenhancing oxidative vitamins
  • vitamin status

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Surgery
  • Medicine (miscellaneous)

Cite this

Liang, B., Chung, S., Araghiniknam, M., Lane, L. C., & Watson, R. R. (1996). Vitamins and immunomodulation in AIDS. Nutrition, 12(1), 1-7. https://doi.org/10.1016/0899-9007(95)00061-5

Vitamins and immunomodulation in AIDS. / Liang, Bailin; Chung, Sangbun; Araghiniknam, Moshen; Lane, Lisa C.; Watson, Ronald R.

In: Nutrition, Vol. 12, No. 1, 1996, p. 1-7.

Research output: Contribution to journalArticle

Liang, B, Chung, S, Araghiniknam, M, Lane, LC & Watson, RR 1996, 'Vitamins and immunomodulation in AIDS', Nutrition, vol. 12, no. 1, pp. 1-7. https://doi.org/10.1016/0899-9007(95)00061-5
Liang, Bailin ; Chung, Sangbun ; Araghiniknam, Moshen ; Lane, Lisa C. ; Watson, Ronald R. / Vitamins and immunomodulation in AIDS. In: Nutrition. 1996 ; Vol. 12, No. 1. pp. 1-7.
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