Volatile nitrites. Use and adverse effects related to the current epidemic of the acquired immune deficiency syndrome

Guy R. Newell, Peter W A Mansell, Margaret R. Spitz, James M. Reuben, Evan M Hersh

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Early reports of the acquired Immune deficiency syndrome (AIDS) in homosexual men suggested that the cause might be related to homosexual life-style practices, including use of recreational drugs. Inhalation of volatile nitrites Is a possible contributing factor In AIDS because their pharmacologic properties lead to toxicity. Metabolism of N-nitroso compounds produces mutagens, teratogens, and potent carcinogens In 39 different animal species, and volatile nitrites have deleterious effects on human lymphocytes in vitro and In vivo. In relation to the current AIDS epidemic, the timing of production and sales of volatile nitrites for recreational use is the only new life-style factor that might answer the question "why AIDS now?" Prevalence of nitrite use among male homosexuals is very high, and almost every reported case of Kaposi's sarcoma during the past three years includes a history of prior nitrite use. The age of the group of patients in whom Kaposl's sarcoma and AIDS are developing is consistent with a cohort Initially exposed seven to 10 years ago. Cessation of nitrite use could reduce the epidemic.

Original languageEnglish (US)
Pages (from-to)811-816
Number of pages6
JournalAmerican Journal of Medicine
Volume78
Issue number5
StatePublished - May 1985
Externally publishedYes

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Nitrites
Acquired Immunodeficiency Syndrome
Life Style
Nitroso Compounds
Teratogens
Kaposi's Sarcoma
Mutagens
Street Drugs
Sarcoma
Carcinogens
Inhalation
Age Groups
Lymphocytes
Sexual Minorities

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Volatile nitrites. Use and adverse effects related to the current epidemic of the acquired immune deficiency syndrome. / Newell, Guy R.; Mansell, Peter W A; Spitz, Margaret R.; Reuben, James M.; Hersh, Evan M.

In: American Journal of Medicine, Vol. 78, No. 5, 05.1985, p. 811-816.

Research output: Contribution to journalArticle

Newell, Guy R. ; Mansell, Peter W A ; Spitz, Margaret R. ; Reuben, James M. ; Hersh, Evan M. / Volatile nitrites. Use and adverse effects related to the current epidemic of the acquired immune deficiency syndrome. In: American Journal of Medicine. 1985 ; Vol. 78, No. 5. pp. 811-816.
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