Volume holographic reflection endoscope for in-vivo ovarian cancer clinical studies

I. D. Howlett, M. Gordon, J. W. Brownlee, Jennifer K Barton, Raymond K Kostuk

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Scopus citations

Abstract

We present the design for an endoscopic system capable of imaging tissues of the ovary at two selected imaging depths simultaneously. The method utilizes a multiplexed volume hologram to select wavefronts from different depths within the tissue. It is the first demonstration of an endoscopic volume holographic imaging system. The endoscope uses both gradient index (GRIN) optical components and off the shelf singlet lenses to relay an image from the distal tip to the proximal end. The endoscope has a minimum diameter of 3.75 mm. The system length is 30 cm which is connected to a handle that includes the holographic components and optics that relay the image to a camera. Preliminary evaluation of the endoscope was performed with tissue phantoms and calibrated targets, which shows lateral resolution 4 μm at an operating wavelength of 660 nm. The hologram is recorded in phenanthraquinone doped poly methacrylate and is designed to produce images from two tissue depths. One image is obtained at the tissue surface and the second 70 μm below the surface. This method requires no mechanical scanning and acquires an image at the camera frame rate. The preliminary ex-vivo results show good correlation with histology sections of the same tissue sections.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
PublisherSPIE
Volume8927
ISBN (Print)9780819498403
DOIs
Publication statusPublished - 2014
EventEndoscopic Microscopy IX; and Optical Techniques in Pulmonary Medicine - San Francisco, CA, United States
Duration: Feb 1 2014Feb 3 2014

Other

OtherEndoscopic Microscopy IX; and Optical Techniques in Pulmonary Medicine
CountryUnited States
CitySan Francisco, CA
Period2/1/142/3/14

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Keywords

  • Endoscopy
  • GRIN
  • Ovarian Cancer
  • Volume holography

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Howlett, I. D., Gordon, M., Brownlee, J. W., Barton, J. K., & Kostuk, R. K. (2014). Volume holographic reflection endoscope for in-vivo ovarian cancer clinical studies. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8927). [89270R] SPIE. https://doi.org/10.1117/12.2037859