Volumetric correlates of spatiotemporal working and recognition memory impairment in aged rhesus monkeys

Jul Lea Shamy, Christian Habeck, Patrick R. Hof, David G. Amaral, Sania G. Fong, Michael H. Buonocore, Yaakov Stern, Carol A Barnes, Peter R. Rapp

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Spatiotemporal and recognition memory are affected by aging in humans and macaque monkeys. To investigate whether these deficits are coupled with atrophy of memory-related brain regions, T1-weighted magnetic resonance images were acquired and volumes of the cerebrum, ventricles, prefrontal cortex (PFC), calcarine cortex, hippocampus, and striatum were quantified in young and aged rhesus monkeys. Subjects were tested on a spatiotemporal memory procedure (delayed response [DR]) that requires the integrity of the PFC and a medial temporal lobe-dependent recognition memory task (delayed nonmatching to sample [DNMS]). Region of interest analyses revealed that age inversely correlated with striatal, dorsolateral prefrontal cortex (dlPFC), and anterior cingulate cortex volumes. Hippocampal volume predicted acquisition of the DR task. Striatal volume correlated with DNMS acquisition, whereas total prefrontal gray matter, prefrontal white matter, and dlPFC volumes each predicted DNMS accuracy. A regional covariance analysis revealed that age-related volumetric changes could be captured in a distributed network that was coupled with declining performance across delays on the DNMS task. This volumetric analysis adds to growing evidence that cognitive aging in primates arises from region-specific morphometric alterations distributed across multiple memory-related brain systems, including subdivisions of the PFC.

Original languageEnglish (US)
Pages (from-to)1559-1573
Number of pages15
JournalCerebral Cortex
Volume21
Issue number7
DOIs
StatePublished - Jul 2011

Fingerprint

Prefrontal Cortex
Macaca mulatta
Short-Term Memory
Repression (Psychology)
Corpus Striatum
Gyrus Cinguli
Brain
Cerebrum
Macaca
Temporal Lobe
Primates
Atrophy
Haplorhini
Hippocampus
Magnetic Resonance Spectroscopy
Recognition (Psychology)

Keywords

  • age-related memory impairment
  • medial temporal lobe
  • MRI
  • prefrontal cortex
  • rhesus monkey

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Shamy, J. L., Habeck, C., Hof, P. R., Amaral, D. G., Fong, S. G., Buonocore, M. H., ... Rapp, P. R. (2011). Volumetric correlates of spatiotemporal working and recognition memory impairment in aged rhesus monkeys. Cerebral Cortex, 21(7), 1559-1573. https://doi.org/10.1093/cercor/bhq210

Volumetric correlates of spatiotemporal working and recognition memory impairment in aged rhesus monkeys. / Shamy, Jul Lea; Habeck, Christian; Hof, Patrick R.; Amaral, David G.; Fong, Sania G.; Buonocore, Michael H.; Stern, Yaakov; Barnes, Carol A; Rapp, Peter R.

In: Cerebral Cortex, Vol. 21, No. 7, 07.2011, p. 1559-1573.

Research output: Contribution to journalArticle

Shamy, JL, Habeck, C, Hof, PR, Amaral, DG, Fong, SG, Buonocore, MH, Stern, Y, Barnes, CA & Rapp, PR 2011, 'Volumetric correlates of spatiotemporal working and recognition memory impairment in aged rhesus monkeys', Cerebral Cortex, vol. 21, no. 7, pp. 1559-1573. https://doi.org/10.1093/cercor/bhq210
Shamy, Jul Lea ; Habeck, Christian ; Hof, Patrick R. ; Amaral, David G. ; Fong, Sania G. ; Buonocore, Michael H. ; Stern, Yaakov ; Barnes, Carol A ; Rapp, Peter R. / Volumetric correlates of spatiotemporal working and recognition memory impairment in aged rhesus monkeys. In: Cerebral Cortex. 2011 ; Vol. 21, No. 7. pp. 1559-1573.
@article{2ab18b0a26714de99aa36c337483db54,
title = "Volumetric correlates of spatiotemporal working and recognition memory impairment in aged rhesus monkeys",
abstract = "Spatiotemporal and recognition memory are affected by aging in humans and macaque monkeys. To investigate whether these deficits are coupled with atrophy of memory-related brain regions, T1-weighted magnetic resonance images were acquired and volumes of the cerebrum, ventricles, prefrontal cortex (PFC), calcarine cortex, hippocampus, and striatum were quantified in young and aged rhesus monkeys. Subjects were tested on a spatiotemporal memory procedure (delayed response [DR]) that requires the integrity of the PFC and a medial temporal lobe-dependent recognition memory task (delayed nonmatching to sample [DNMS]). Region of interest analyses revealed that age inversely correlated with striatal, dorsolateral prefrontal cortex (dlPFC), and anterior cingulate cortex volumes. Hippocampal volume predicted acquisition of the DR task. Striatal volume correlated with DNMS acquisition, whereas total prefrontal gray matter, prefrontal white matter, and dlPFC volumes each predicted DNMS accuracy. A regional covariance analysis revealed that age-related volumetric changes could be captured in a distributed network that was coupled with declining performance across delays on the DNMS task. This volumetric analysis adds to growing evidence that cognitive aging in primates arises from region-specific morphometric alterations distributed across multiple memory-related brain systems, including subdivisions of the PFC.",
keywords = "age-related memory impairment, medial temporal lobe, MRI, prefrontal cortex, rhesus monkey",
author = "Shamy, {Jul Lea} and Christian Habeck and Hof, {Patrick R.} and Amaral, {David G.} and Fong, {Sania G.} and Buonocore, {Michael H.} and Yaakov Stern and Barnes, {Carol A} and Rapp, {Peter R.}",
year = "2011",
month = "7",
doi = "10.1093/cercor/bhq210",
language = "English (US)",
volume = "21",
pages = "1559--1573",
journal = "Cerebral Cortex",
issn = "1047-3211",
publisher = "Oxford University Press",
number = "7",

}

TY - JOUR

T1 - Volumetric correlates of spatiotemporal working and recognition memory impairment in aged rhesus monkeys

AU - Shamy, Jul Lea

AU - Habeck, Christian

AU - Hof, Patrick R.

AU - Amaral, David G.

AU - Fong, Sania G.

AU - Buonocore, Michael H.

AU - Stern, Yaakov

AU - Barnes, Carol A

AU - Rapp, Peter R.

PY - 2011/7

Y1 - 2011/7

N2 - Spatiotemporal and recognition memory are affected by aging in humans and macaque monkeys. To investigate whether these deficits are coupled with atrophy of memory-related brain regions, T1-weighted magnetic resonance images were acquired and volumes of the cerebrum, ventricles, prefrontal cortex (PFC), calcarine cortex, hippocampus, and striatum were quantified in young and aged rhesus monkeys. Subjects were tested on a spatiotemporal memory procedure (delayed response [DR]) that requires the integrity of the PFC and a medial temporal lobe-dependent recognition memory task (delayed nonmatching to sample [DNMS]). Region of interest analyses revealed that age inversely correlated with striatal, dorsolateral prefrontal cortex (dlPFC), and anterior cingulate cortex volumes. Hippocampal volume predicted acquisition of the DR task. Striatal volume correlated with DNMS acquisition, whereas total prefrontal gray matter, prefrontal white matter, and dlPFC volumes each predicted DNMS accuracy. A regional covariance analysis revealed that age-related volumetric changes could be captured in a distributed network that was coupled with declining performance across delays on the DNMS task. This volumetric analysis adds to growing evidence that cognitive aging in primates arises from region-specific morphometric alterations distributed across multiple memory-related brain systems, including subdivisions of the PFC.

AB - Spatiotemporal and recognition memory are affected by aging in humans and macaque monkeys. To investigate whether these deficits are coupled with atrophy of memory-related brain regions, T1-weighted magnetic resonance images were acquired and volumes of the cerebrum, ventricles, prefrontal cortex (PFC), calcarine cortex, hippocampus, and striatum were quantified in young and aged rhesus monkeys. Subjects were tested on a spatiotemporal memory procedure (delayed response [DR]) that requires the integrity of the PFC and a medial temporal lobe-dependent recognition memory task (delayed nonmatching to sample [DNMS]). Region of interest analyses revealed that age inversely correlated with striatal, dorsolateral prefrontal cortex (dlPFC), and anterior cingulate cortex volumes. Hippocampal volume predicted acquisition of the DR task. Striatal volume correlated with DNMS acquisition, whereas total prefrontal gray matter, prefrontal white matter, and dlPFC volumes each predicted DNMS accuracy. A regional covariance analysis revealed that age-related volumetric changes could be captured in a distributed network that was coupled with declining performance across delays on the DNMS task. This volumetric analysis adds to growing evidence that cognitive aging in primates arises from region-specific morphometric alterations distributed across multiple memory-related brain systems, including subdivisions of the PFC.

KW - age-related memory impairment

KW - medial temporal lobe

KW - MRI

KW - prefrontal cortex

KW - rhesus monkey

UR - http://www.scopus.com/inward/record.url?scp=79959481908&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79959481908&partnerID=8YFLogxK

U2 - 10.1093/cercor/bhq210

DO - 10.1093/cercor/bhq210

M3 - Article

C2 - 21127015

AN - SCOPUS:79959481908

VL - 21

SP - 1559

EP - 1573

JO - Cerebral Cortex

JF - Cerebral Cortex

SN - 1047-3211

IS - 7

ER -