Warfarin safety and efficacy in patients with thoracic aortic plaque and atrial fibrillation

Joseph L. Blackshear, Miguel Zabalgoitia, Gregory Pennock, Paul E Fenster, Richard Strauss, Jonathan Halperin, Richard Asinger, Lesly A. Pearce

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Patients with atrial fibrillation and with documented oartic plaque who were assigned to adjusted-dose warfarin therapy (international normalized ratio 2.0 to 3.0) had an annual rate of cholesterol embolization of 0.7% (95% confidence interval [CI] 0.1% to 5.3%/patient-year). Warfarin-assigned patients with plaque had a lower rate of embolic events (5.9%/year; 95% CI 3.0 to 12) than those on combination low-dose warfarin (international normalized ratio <1.5) plus aspirin (17.3%/year; 95% CI 11 to 27; p = 0.01).

Original languageEnglish (US)
Pages (from-to)453-455
Number of pages3
JournalThe American journal of cardiology
Volume83
Issue number3
DOIs
StatePublished - Feb 1 1999

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Warfarin
Atrial Fibrillation
International Normalized Ratio
Thorax
Confidence Intervals
Safety
Aspirin
Cholesterol
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Warfarin safety and efficacy in patients with thoracic aortic plaque and atrial fibrillation. / Blackshear, Joseph L.; Zabalgoitia, Miguel; Pennock, Gregory; Fenster, Paul E; Strauss, Richard; Halperin, Jonathan; Asinger, Richard; Pearce, Lesly A.

In: The American journal of cardiology, Vol. 83, No. 3, 01.02.1999, p. 453-455.

Research output: Contribution to journalArticle

Blackshear, JL, Zabalgoitia, M, Pennock, G, Fenster, PE, Strauss, R, Halperin, J, Asinger, R & Pearce, LA 1999, 'Warfarin safety and efficacy in patients with thoracic aortic plaque and atrial fibrillation', The American journal of cardiology, vol. 83, no. 3, pp. 453-455. https://doi.org/10.1016/S0002-9149(98)00886-8
Blackshear, Joseph L. ; Zabalgoitia, Miguel ; Pennock, Gregory ; Fenster, Paul E ; Strauss, Richard ; Halperin, Jonathan ; Asinger, Richard ; Pearce, Lesly A. / Warfarin safety and efficacy in patients with thoracic aortic plaque and atrial fibrillation. In: The American journal of cardiology. 1999 ; Vol. 83, No. 3. pp. 453-455.
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