Weight change during childhood acute lymphoblastic leukemia induction therapy predicts obesity: A report from the children's oncology group

Janice S. Withycombe, Lynette M. Smith, Jane L. Meza, Carrie J Merkle, Melissa Spezia Faulkner, Leslie S Ritter, Nita L. Seibel, Ida M Moore

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Background: Obesity is a well documented problem associated with childhood acute lymphoblastic leukemia (ALL) with increasing body mass index often observed during therapy. This study aims to evaluate if weight gain, early in therapy, is predictive of obesity at the end of treatment. Procedure: In this secondary analysis, data from 1,017 high-risk ALL patients previously treated on a Children's Oncology Group protocol (CCG study 1961) were reviewed. Logistic regression was used to examine whether change in BMI z-score at Induction or Delayed Intensification (DI) 1 were predictive of obesity at the end of therapy. Results: The BMI z-score at the beginning of Induction and the change in BMI z-score during Induction were both significant predictors of obesity at the end of therapy. The change in BMI z-score during cycle 1 of DI was not found to be associated with obesity. Conclusions: It is well know that obesity at the beginning of therapy is predictive of obesity at the end of ALL therapy. The new, and more important, finding from this study is that even after adjusting for baseline weight, the increase in BMI z-scores during induction was an independent predictor of obesity at the end of therapy. Most researchers agree that prevention is the best form of treatment for obesity as it is difficult to reverse once it is present. This study suggests that monitoring weight trends during Induction may be useful in guiding healthcare practitioners in identifying which patients are at highest risk for obesity development so that early intervention may occur.

Original languageEnglish (US)
Pages (from-to)434-439
Number of pages6
JournalPediatric Blood and Cancer
Volume62
Issue number3
DOIs
StatePublished - Mar 1 2015

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Precursor Cell Lymphoblastic Leukemia-Lymphoma
Obesity
Weights and Measures
Therapeutics
Secondary Prevention
Weight Gain
Body Mass Index
Logistic Models
Research Personnel
Delivery of Health Care

Keywords

  • Acute lymphoblastic leukemia
  • Childhood
  • Obesity
  • Weight gain

ASJC Scopus subject areas

  • Oncology
  • Pediatrics, Perinatology, and Child Health
  • Hematology

Cite this

Weight change during childhood acute lymphoblastic leukemia induction therapy predicts obesity : A report from the children's oncology group. / Withycombe, Janice S.; Smith, Lynette M.; Meza, Jane L.; Merkle, Carrie J; Faulkner, Melissa Spezia; Ritter, Leslie S; Seibel, Nita L.; Moore, Ida M.

In: Pediatric Blood and Cancer, Vol. 62, No. 3, 01.03.2015, p. 434-439.

Research output: Contribution to journalArticle

Withycombe, Janice S. ; Smith, Lynette M. ; Meza, Jane L. ; Merkle, Carrie J ; Faulkner, Melissa Spezia ; Ritter, Leslie S ; Seibel, Nita L. ; Moore, Ida M. / Weight change during childhood acute lymphoblastic leukemia induction therapy predicts obesity : A report from the children's oncology group. In: Pediatric Blood and Cancer. 2015 ; Vol. 62, No. 3. pp. 434-439.
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