Weight-loss induced changes in plasma factor VII coagulant activity and relation to the factor VII Arg/Gln353 polymorphism in moderately obese adults

James S. Pankow, Aaron R. Folsom, Eyal Shahar, Michael Y. Tsai, Robert W. Jeffery, Rena R. Wing

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Elevated plasma factor VII coagulant activity (factor VIIc) may be an independent risk factor for coronary heart disease. Several cross-sectional studies suggest that a polymorphism of the factor VII gene (Arg-Gln353) interacts with plasma triglyceride level in determining: factor VIIc, but prospective data are lacking. Factor VII genotype, factor VIIc, and triglyceride level were measured in moderately obese adults aged 25 to 45 who underwent a six-month clinical trial to evaluate strategies for weight loss. A total of 48 men and 50 women who experienced substantial weight loss (mean: 10 kg) provided samples for genetic analysis. Overall, 78% of participants were homozygous for the Arg353 allele, while the remaining 22% were heterozygous (Arg/Gln353). At the baseline examination, heterozygotes had lower mean factor VIIc than Arg-353 homozygotes (92% vs. 112%; p < 0.001), and genotype explained 18% of the variance of factor VIIc. Average six-month weight loss was similar in both genotypes; mean reductions in factor VIIc following weight loss were greatest among Arg353 homozygotes with high initial values ( > 120%). Cross-sectional and longitudinal associations between plasma factor VIIc and triglyceride level were not dependent on genotype. These data confirm that the Gln353 allele is associated with lower factor VII coagulant activity in moderately obese adults, but they do not support the hypothesis that the Arg-Gln353 polymorphism interacts with plasma triglyceride level in determining factor VIIc.

Original languageEnglish (US)
Pages (from-to)784-789
Number of pages6
JournalThrombosis and Haemostasis
Volume79
Issue number4
StatePublished - Apr 1998
Externally publishedYes

Fingerprint

Factor VII
Weight Loss
Triglycerides
Alleles
Genotype
Homozygote
Heterozygote
factor VII clotting antigen
Coronary Disease
Cross-Sectional Studies
Clinical Trials
Genes

ASJC Scopus subject areas

  • Hematology

Cite this

Weight-loss induced changes in plasma factor VII coagulant activity and relation to the factor VII Arg/Gln353 polymorphism in moderately obese adults. / Pankow, James S.; Folsom, Aaron R.; Shahar, Eyal; Tsai, Michael Y.; Jeffery, Robert W.; Wing, Rena R.

In: Thrombosis and Haemostasis, Vol. 79, No. 4, 04.1998, p. 784-789.

Research output: Contribution to journalArticle

Pankow, James S. ; Folsom, Aaron R. ; Shahar, Eyal ; Tsai, Michael Y. ; Jeffery, Robert W. ; Wing, Rena R. / Weight-loss induced changes in plasma factor VII coagulant activity and relation to the factor VII Arg/Gln353 polymorphism in moderately obese adults. In: Thrombosis and Haemostasis. 1998 ; Vol. 79, No. 4. pp. 784-789.
@article{dad58c9bc372452dbecb49b0bd1787a0,
title = "Weight-loss induced changes in plasma factor VII coagulant activity and relation to the factor VII Arg/Gln353 polymorphism in moderately obese adults",
abstract = "Elevated plasma factor VII coagulant activity (factor VIIc) may be an independent risk factor for coronary heart disease. Several cross-sectional studies suggest that a polymorphism of the factor VII gene (Arg-Gln353) interacts with plasma triglyceride level in determining: factor VIIc, but prospective data are lacking. Factor VII genotype, factor VIIc, and triglyceride level were measured in moderately obese adults aged 25 to 45 who underwent a six-month clinical trial to evaluate strategies for weight loss. A total of 48 men and 50 women who experienced substantial weight loss (mean: 10 kg) provided samples for genetic analysis. Overall, 78{\%} of participants were homozygous for the Arg353 allele, while the remaining 22{\%} were heterozygous (Arg/Gln353). At the baseline examination, heterozygotes had lower mean factor VIIc than Arg-353 homozygotes (92{\%} vs. 112{\%}; p < 0.001), and genotype explained 18{\%} of the variance of factor VIIc. Average six-month weight loss was similar in both genotypes; mean reductions in factor VIIc following weight loss were greatest among Arg353 homozygotes with high initial values ( > 120{\%}). Cross-sectional and longitudinal associations between plasma factor VIIc and triglyceride level were not dependent on genotype. These data confirm that the Gln353 allele is associated with lower factor VII coagulant activity in moderately obese adults, but they do not support the hypothesis that the Arg-Gln353 polymorphism interacts with plasma triglyceride level in determining factor VIIc.",
author = "Pankow, {James S.} and Folsom, {Aaron R.} and Eyal Shahar and Tsai, {Michael Y.} and Jeffery, {Robert W.} and Wing, {Rena R.}",
year = "1998",
month = "4",
language = "English (US)",
volume = "79",
pages = "784--789",
journal = "Thrombosis and Haemostasis",
issn = "0340-6245",
publisher = "Schattauer GmbH",
number = "4",

}

TY - JOUR

T1 - Weight-loss induced changes in plasma factor VII coagulant activity and relation to the factor VII Arg/Gln353 polymorphism in moderately obese adults

AU - Pankow, James S.

AU - Folsom, Aaron R.

AU - Shahar, Eyal

AU - Tsai, Michael Y.

AU - Jeffery, Robert W.

AU - Wing, Rena R.

PY - 1998/4

Y1 - 1998/4

N2 - Elevated plasma factor VII coagulant activity (factor VIIc) may be an independent risk factor for coronary heart disease. Several cross-sectional studies suggest that a polymorphism of the factor VII gene (Arg-Gln353) interacts with plasma triglyceride level in determining: factor VIIc, but prospective data are lacking. Factor VII genotype, factor VIIc, and triglyceride level were measured in moderately obese adults aged 25 to 45 who underwent a six-month clinical trial to evaluate strategies for weight loss. A total of 48 men and 50 women who experienced substantial weight loss (mean: 10 kg) provided samples for genetic analysis. Overall, 78% of participants were homozygous for the Arg353 allele, while the remaining 22% were heterozygous (Arg/Gln353). At the baseline examination, heterozygotes had lower mean factor VIIc than Arg-353 homozygotes (92% vs. 112%; p < 0.001), and genotype explained 18% of the variance of factor VIIc. Average six-month weight loss was similar in both genotypes; mean reductions in factor VIIc following weight loss were greatest among Arg353 homozygotes with high initial values ( > 120%). Cross-sectional and longitudinal associations between plasma factor VIIc and triglyceride level were not dependent on genotype. These data confirm that the Gln353 allele is associated with lower factor VII coagulant activity in moderately obese adults, but they do not support the hypothesis that the Arg-Gln353 polymorphism interacts with plasma triglyceride level in determining factor VIIc.

AB - Elevated plasma factor VII coagulant activity (factor VIIc) may be an independent risk factor for coronary heart disease. Several cross-sectional studies suggest that a polymorphism of the factor VII gene (Arg-Gln353) interacts with plasma triglyceride level in determining: factor VIIc, but prospective data are lacking. Factor VII genotype, factor VIIc, and triglyceride level were measured in moderately obese adults aged 25 to 45 who underwent a six-month clinical trial to evaluate strategies for weight loss. A total of 48 men and 50 women who experienced substantial weight loss (mean: 10 kg) provided samples for genetic analysis. Overall, 78% of participants were homozygous for the Arg353 allele, while the remaining 22% were heterozygous (Arg/Gln353). At the baseline examination, heterozygotes had lower mean factor VIIc than Arg-353 homozygotes (92% vs. 112%; p < 0.001), and genotype explained 18% of the variance of factor VIIc. Average six-month weight loss was similar in both genotypes; mean reductions in factor VIIc following weight loss were greatest among Arg353 homozygotes with high initial values ( > 120%). Cross-sectional and longitudinal associations between plasma factor VIIc and triglyceride level were not dependent on genotype. These data confirm that the Gln353 allele is associated with lower factor VII coagulant activity in moderately obese adults, but they do not support the hypothesis that the Arg-Gln353 polymorphism interacts with plasma triglyceride level in determining factor VIIc.

UR - http://www.scopus.com/inward/record.url?scp=0031957973&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031957973&partnerID=8YFLogxK

M3 - Article

C2 - 9569193

AN - SCOPUS:0031957973

VL - 79

SP - 784

EP - 789

JO - Thrombosis and Haemostasis

JF - Thrombosis and Haemostasis

SN - 0340-6245

IS - 4

ER -