What comes first? multitissue involvement leading to radiographic osteoarthritis: Magnetic resonance imaging-based trajectory analysis over four years in the osteoarthritis initiative

Frank W. Roemer, Chian K Kwoh, Michael J. Hannon, David J. Hunter, Felix Eckstein, Tomoko Fujii, Robert M. Boudreau, Ali Guermazi

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Objective To assess whether the presence of structural osteoarthritis (OA) features over as many as 4 years prior to incident radiographic OA increases the risk of radiographic OA in a nested, case-control design. Methods We studied 355 knees from the Osteoarthritis Initiative cohort that developed radiographic OA before the 48-month visit. They were matched one-to-one by sex, age, and contralateral knee radiographic status with a control knee. Magnetic resonance images (MRIs) were read for bone marrow lesions (BMLs), cartilage damage, meniscal damage (including tears and extrusion), Hoffa synovitis, and effusion synovitis. Conditional logistic regression was applied to assess the risk of radiographic OA with regard to the presence of BMLs (score ≥2), cartilage lesions (score ≥1.1), meniscal damage (any) and extrusion of ≥3 mm ± (score ≥2), and Hoffa and effusion synovitis (any). Time points were defined as incident radiographic OA visit (P0), 1 year prior to the detection of radiographic OA (P -1), 2 years prior to the detection of radiographic OA (P -2), etc. Results The presence of Hoffa synovitis (hazard ratio [HR] 1.76 [95% confidence interval (95% CI) 1.18-2.64]), effusion synovitis (HR 1.81 [95% CI 1.18-2.78]), and medial meniscal damage (HR 1.83 [95% CI 1.17-2.89]) at P -2 predicted radiographic OA incidence. At P -1, all features but meniscal extrusion predicted radiographic OA, with highest odds for medial BMLs (HR 6.50 [95% CI 2.27-18.62]) and effusion synovitis (HR 2.50 [95% CI 1.76-3.54]). The findings at P -3 and P -4 did not reach statistical significance. Conclusion Our findings indicate that the presence of specific structural features of MRI-detected joint damage 2 years prior to incident radiographic OA increases the risk of incident radiographic OA. However, 1 year prior to radiographic OA, the presence of almost any abnormal morphologic feature increases the risk of radiographic OA in the subsequent year.

Original languageEnglish (US)
Pages (from-to)2085-2096
Number of pages12
JournalArthritis and Rheumatology
Volume67
Issue number8
DOIs
StatePublished - Aug 1 2015

Fingerprint

Osteoarthritis
Magnetic Resonance Imaging
Synovitis
Confidence Intervals
Bone Marrow
Cartilage
Knee
Magnetic Resonance Spectroscopy
Knee Osteoarthritis
Tears
Joints
Logistic Models

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Rheumatology

Cite this

What comes first? multitissue involvement leading to radiographic osteoarthritis : Magnetic resonance imaging-based trajectory analysis over four years in the osteoarthritis initiative. / Roemer, Frank W.; Kwoh, Chian K; Hannon, Michael J.; Hunter, David J.; Eckstein, Felix; Fujii, Tomoko; Boudreau, Robert M.; Guermazi, Ali.

In: Arthritis and Rheumatology, Vol. 67, No. 8, 01.08.2015, p. 2085-2096.

Research output: Contribution to journalArticle

Roemer, Frank W. ; Kwoh, Chian K ; Hannon, Michael J. ; Hunter, David J. ; Eckstein, Felix ; Fujii, Tomoko ; Boudreau, Robert M. ; Guermazi, Ali. / What comes first? multitissue involvement leading to radiographic osteoarthritis : Magnetic resonance imaging-based trajectory analysis over four years in the osteoarthritis initiative. In: Arthritis and Rheumatology. 2015 ; Vol. 67, No. 8. pp. 2085-2096.
@article{2965f4861dc84fa0863c90de542831c7,
title = "What comes first? multitissue involvement leading to radiographic osteoarthritis: Magnetic resonance imaging-based trajectory analysis over four years in the osteoarthritis initiative",
abstract = "Objective To assess whether the presence of structural osteoarthritis (OA) features over as many as 4 years prior to incident radiographic OA increases the risk of radiographic OA in a nested, case-control design. Methods We studied 355 knees from the Osteoarthritis Initiative cohort that developed radiographic OA before the 48-month visit. They were matched one-to-one by sex, age, and contralateral knee radiographic status with a control knee. Magnetic resonance images (MRIs) were read for bone marrow lesions (BMLs), cartilage damage, meniscal damage (including tears and extrusion), Hoffa synovitis, and effusion synovitis. Conditional logistic regression was applied to assess the risk of radiographic OA with regard to the presence of BMLs (score ≥2), cartilage lesions (score ≥1.1), meniscal damage (any) and extrusion of ≥3 mm ± (score ≥2), and Hoffa and effusion synovitis (any). Time points were defined as incident radiographic OA visit (P0), 1 year prior to the detection of radiographic OA (P -1), 2 years prior to the detection of radiographic OA (P -2), etc. Results The presence of Hoffa synovitis (hazard ratio [HR] 1.76 [95{\%} confidence interval (95{\%} CI) 1.18-2.64]), effusion synovitis (HR 1.81 [95{\%} CI 1.18-2.78]), and medial meniscal damage (HR 1.83 [95{\%} CI 1.17-2.89]) at P -2 predicted radiographic OA incidence. At P -1, all features but meniscal extrusion predicted radiographic OA, with highest odds for medial BMLs (HR 6.50 [95{\%} CI 2.27-18.62]) and effusion synovitis (HR 2.50 [95{\%} CI 1.76-3.54]). The findings at P -3 and P -4 did not reach statistical significance. Conclusion Our findings indicate that the presence of specific structural features of MRI-detected joint damage 2 years prior to incident radiographic OA increases the risk of incident radiographic OA. However, 1 year prior to radiographic OA, the presence of almost any abnormal morphologic feature increases the risk of radiographic OA in the subsequent year.",
author = "Roemer, {Frank W.} and Kwoh, {Chian K} and Hannon, {Michael J.} and Hunter, {David J.} and Felix Eckstein and Tomoko Fujii and Boudreau, {Robert M.} and Ali Guermazi",
year = "2015",
month = "8",
day = "1",
doi = "10.1002/art.39176",
language = "English (US)",
volume = "67",
pages = "2085--2096",
journal = "Arthritis and Rheumatology",
issn = "2326-5191",
publisher = "John Wiley and Sons Ltd",
number = "8",

}

TY - JOUR

T1 - What comes first? multitissue involvement leading to radiographic osteoarthritis

T2 - Magnetic resonance imaging-based trajectory analysis over four years in the osteoarthritis initiative

AU - Roemer, Frank W.

AU - Kwoh, Chian K

AU - Hannon, Michael J.

AU - Hunter, David J.

AU - Eckstein, Felix

AU - Fujii, Tomoko

AU - Boudreau, Robert M.

AU - Guermazi, Ali

PY - 2015/8/1

Y1 - 2015/8/1

N2 - Objective To assess whether the presence of structural osteoarthritis (OA) features over as many as 4 years prior to incident radiographic OA increases the risk of radiographic OA in a nested, case-control design. Methods We studied 355 knees from the Osteoarthritis Initiative cohort that developed radiographic OA before the 48-month visit. They were matched one-to-one by sex, age, and contralateral knee radiographic status with a control knee. Magnetic resonance images (MRIs) were read for bone marrow lesions (BMLs), cartilage damage, meniscal damage (including tears and extrusion), Hoffa synovitis, and effusion synovitis. Conditional logistic regression was applied to assess the risk of radiographic OA with regard to the presence of BMLs (score ≥2), cartilage lesions (score ≥1.1), meniscal damage (any) and extrusion of ≥3 mm ± (score ≥2), and Hoffa and effusion synovitis (any). Time points were defined as incident radiographic OA visit (P0), 1 year prior to the detection of radiographic OA (P -1), 2 years prior to the detection of radiographic OA (P -2), etc. Results The presence of Hoffa synovitis (hazard ratio [HR] 1.76 [95% confidence interval (95% CI) 1.18-2.64]), effusion synovitis (HR 1.81 [95% CI 1.18-2.78]), and medial meniscal damage (HR 1.83 [95% CI 1.17-2.89]) at P -2 predicted radiographic OA incidence. At P -1, all features but meniscal extrusion predicted radiographic OA, with highest odds for medial BMLs (HR 6.50 [95% CI 2.27-18.62]) and effusion synovitis (HR 2.50 [95% CI 1.76-3.54]). The findings at P -3 and P -4 did not reach statistical significance. Conclusion Our findings indicate that the presence of specific structural features of MRI-detected joint damage 2 years prior to incident radiographic OA increases the risk of incident radiographic OA. However, 1 year prior to radiographic OA, the presence of almost any abnormal morphologic feature increases the risk of radiographic OA in the subsequent year.

AB - Objective To assess whether the presence of structural osteoarthritis (OA) features over as many as 4 years prior to incident radiographic OA increases the risk of radiographic OA in a nested, case-control design. Methods We studied 355 knees from the Osteoarthritis Initiative cohort that developed radiographic OA before the 48-month visit. They were matched one-to-one by sex, age, and contralateral knee radiographic status with a control knee. Magnetic resonance images (MRIs) were read for bone marrow lesions (BMLs), cartilage damage, meniscal damage (including tears and extrusion), Hoffa synovitis, and effusion synovitis. Conditional logistic regression was applied to assess the risk of radiographic OA with regard to the presence of BMLs (score ≥2), cartilage lesions (score ≥1.1), meniscal damage (any) and extrusion of ≥3 mm ± (score ≥2), and Hoffa and effusion synovitis (any). Time points were defined as incident radiographic OA visit (P0), 1 year prior to the detection of radiographic OA (P -1), 2 years prior to the detection of radiographic OA (P -2), etc. Results The presence of Hoffa synovitis (hazard ratio [HR] 1.76 [95% confidence interval (95% CI) 1.18-2.64]), effusion synovitis (HR 1.81 [95% CI 1.18-2.78]), and medial meniscal damage (HR 1.83 [95% CI 1.17-2.89]) at P -2 predicted radiographic OA incidence. At P -1, all features but meniscal extrusion predicted radiographic OA, with highest odds for medial BMLs (HR 6.50 [95% CI 2.27-18.62]) and effusion synovitis (HR 2.50 [95% CI 1.76-3.54]). The findings at P -3 and P -4 did not reach statistical significance. Conclusion Our findings indicate that the presence of specific structural features of MRI-detected joint damage 2 years prior to incident radiographic OA increases the risk of incident radiographic OA. However, 1 year prior to radiographic OA, the presence of almost any abnormal morphologic feature increases the risk of radiographic OA in the subsequent year.

UR - http://www.scopus.com/inward/record.url?scp=84938151983&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84938151983&partnerID=8YFLogxK

U2 - 10.1002/art.39176

DO - 10.1002/art.39176

M3 - Article

C2 - 25940308

AN - SCOPUS:84938151983

VL - 67

SP - 2085

EP - 2096

JO - Arthritis and Rheumatology

JF - Arthritis and Rheumatology

SN - 2326-5191

IS - 8

ER -