Which tautomeric form of 5-methylcytosine predominates in vacuum?

Andrzej Leś, Ludwik Adamowicz

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

An application of high-level ab initio quantum chemistry methods to study the tautomeric equilibria of 5-methylcytosine in the gas-phase is described. Calculations for the hydroxy-amino, oxo-amino and oxo-imino forms have been performed at the second-order level of the many body perturbation theory (MBPT(2)) with a double-zeta basis set augmented with polarization functions. The optimized geometry and vibrational modes were obtained with the SCF/3-21G method. The calculations clearly show that the most stable tautomeric form in vacuum is hydroxy-amino. The remaining two forms, i.e. oxo-amino and oxo-imino, are each estimated to be less stable than the main form by about 15 kJ mol-1.

Original languageEnglish (US)
Pages (from-to)209-218
Number of pages10
JournalJournal of Molecular Structure
Volume221
Issue numberC
DOIs
StatePublished - Apr 30 1990

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5-Methylcytosine
Vacuum
Quantum chemistry
vacuum
quantum chemistry
self consistent fields
vibration mode
perturbation theory
Gases
Polarization
vapor phases
Geometry
polarization
geometry

ASJC Scopus subject areas

  • Structural Biology
  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Spectroscopy
  • Materials Science (miscellaneous)
  • Atomic and Molecular Physics, and Optics

Cite this

Which tautomeric form of 5-methylcytosine predominates in vacuum? / Leś, Andrzej; Adamowicz, Ludwik.

In: Journal of Molecular Structure, Vol. 221, No. C, 30.04.1990, p. 209-218.

Research output: Contribution to journalArticle

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