White matter integrity in older females is altered by increased body fat

T Lee Ryan, Katrin Walther

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objective To assess whether the pattern of diffusion changes among a cohort of individuals showing BMI-related increases in white matter volume reflects healthy expansion of myelin or damaged white matter. Methods Diffusion MRI measures (axial, radial, and fractional anisotropy) were obtained from 94 females, aged 52-92. Relationships between BMI and diffusion measures were assessed controlling for age, hypertension, and diabetes status using general linear modeling. Associations between diffusion measures and cognitive status (memory, executive functions, and visuomotor speed) were assessed using multiple regressions, controlling for age, education, hypertension, and diabetes status. Results Higher levels of BMI were associated with lower axial diffusion in frontal, temporal, parietal, internal capsule, and cerebellar white matter. Lower fractional anisotropy was observed in bilateral temporal white matter and the right corticospinal tract, with higher radial diffusion in temporal and temporoparietal white matter. Importantly, diffusion measures predicted reductions in executive functioning, memory, and visuomotor speed. Conclusions The pattern of diffusion changes in regions of white matter showing BMI-related volume increases are not due to expansion of normal myelin, but instead suggests damage to white matter that has important consequences for cognitive functioning.

Original languageEnglish (US)
Pages (from-to)2039-2046
Number of pages8
JournalObesity
Volume22
Issue number9
DOIs
StatePublished - 2014

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Adipose Tissue
Anisotropy
Myelin Sheath
Hypertension
Internal Capsule
Pyramidal Tracts
Diffusion Magnetic Resonance Imaging
Executive Function
White Matter
Education

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

White matter integrity in older females is altered by increased body fat. / Ryan, T Lee; Walther, Katrin.

In: Obesity, Vol. 22, No. 9, 2014, p. 2039-2046.

Research output: Contribution to journalArticle

Ryan, T Lee ; Walther, Katrin. / White matter integrity in older females is altered by increased body fat. In: Obesity. 2014 ; Vol. 22, No. 9. pp. 2039-2046.
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