Withdrawal following cocaine self-administration decreases regional cerebral metabolic rate in critical brain reward regions

Ronald P Hammer, W. S. Pires, A. Markou, G. F. Koob

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The quantitative [14C]-2-deoxyglucose autoradiographic method was utilized to assess regional cerebral metabolic rate for glucose (rCMR(glc)) in rat brain during withdrawal from cocaine self-administration. RCMR(glc) was determined in 62 regions from brains of naive rats which were placed into an empty operant chamber for 12 hr continuously, and rats trained to self- administer cocaine during 3 hr training sessions and subsequently placed into the operant chamber for 12 hr continuously with or without access to cocaine. Animals placed into the chamber without access to cocaine were examined 6 hr later, while animals allowed access to the 12 hr cocaine binge were examined either 6 or 72 hr post-cocaine. Metabolic activity was reduced during withdrawal in the nucleus accumbens, olfactory tubercle, islands of Calleja region, basolateral and central amygdaloid nuclei, medial septum, piriform and cingulate cortices, rostral caudatoputamen, entopeduncular nucleus and the adjacent lateral hypothalamus, somatosensory, auditory, and motor cortices compared to the naive state. These effects were usually more severe at 72 than at 6 hr after binge exposure, with intermediate values observed in cocaine trained animals without binge exposure. The response was negatively correlated with the amount of cocaine consumed during binge exposure in the striatum, olfactory tubercle, piriform, cingulate, somatosensory, and motor cortices. Thus, the amount of cocaine consumed can affect the extent of metabolic depression after sustained drug exposure. The pattern of regional effects suggests that mesolimbic and rostral extrapyramidal dopamine terminal regions and certain of their efferent pathways are preferentially affected during cocaine withdrawal. The reduction of basal metabolic rate observed in these brain regions during cocaine withdrawal may become more severe with time despite the apparent recovery of certain behavioral-motivational responses.

Original languageEnglish (US)
Pages (from-to)73-80
Number of pages8
JournalSynapse
Volume14
Issue number1
StatePublished - 1993
Externally publishedYes

Fingerprint

Self Administration
Reward
Cocaine
Brain
Somatosensory Cortex
Gyrus Cinguli
Motor Cortex
Islands of Calleja
Entopeduncular Nucleus
Lateral Hypothalamic Area
Efferent Pathways
Glucose
Basal Metabolism
Auditory Cortex
Deoxyglucose
Nucleus Accumbens
Dopamine

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)
  • Pharmacology

Cite this

Withdrawal following cocaine self-administration decreases regional cerebral metabolic rate in critical brain reward regions. / Hammer, Ronald P; Pires, W. S.; Markou, A.; Koob, G. F.

In: Synapse, Vol. 14, No. 1, 1993, p. 73-80.

Research output: Contribution to journalArticle

@article{bf634d9ea7de4e10bb9dcc27042c845c,
title = "Withdrawal following cocaine self-administration decreases regional cerebral metabolic rate in critical brain reward regions",
abstract = "The quantitative [14C]-2-deoxyglucose autoradiographic method was utilized to assess regional cerebral metabolic rate for glucose (rCMR(glc)) in rat brain during withdrawal from cocaine self-administration. RCMR(glc) was determined in 62 regions from brains of naive rats which were placed into an empty operant chamber for 12 hr continuously, and rats trained to self- administer cocaine during 3 hr training sessions and subsequently placed into the operant chamber for 12 hr continuously with or without access to cocaine. Animals placed into the chamber without access to cocaine were examined 6 hr later, while animals allowed access to the 12 hr cocaine binge were examined either 6 or 72 hr post-cocaine. Metabolic activity was reduced during withdrawal in the nucleus accumbens, olfactory tubercle, islands of Calleja region, basolateral and central amygdaloid nuclei, medial septum, piriform and cingulate cortices, rostral caudatoputamen, entopeduncular nucleus and the adjacent lateral hypothalamus, somatosensory, auditory, and motor cortices compared to the naive state. These effects were usually more severe at 72 than at 6 hr after binge exposure, with intermediate values observed in cocaine trained animals without binge exposure. The response was negatively correlated with the amount of cocaine consumed during binge exposure in the striatum, olfactory tubercle, piriform, cingulate, somatosensory, and motor cortices. Thus, the amount of cocaine consumed can affect the extent of metabolic depression after sustained drug exposure. The pattern of regional effects suggests that mesolimbic and rostral extrapyramidal dopamine terminal regions and certain of their efferent pathways are preferentially affected during cocaine withdrawal. The reduction of basal metabolic rate observed in these brain regions during cocaine withdrawal may become more severe with time despite the apparent recovery of certain behavioral-motivational responses.",
author = "Hammer, {Ronald P} and Pires, {W. S.} and A. Markou and Koob, {G. F.}",
year = "1993",
language = "English (US)",
volume = "14",
pages = "73--80",
journal = "Synapse",
issn = "0887-4476",
publisher = "Wiley-Liss Inc.",
number = "1",

}

TY - JOUR

T1 - Withdrawal following cocaine self-administration decreases regional cerebral metabolic rate in critical brain reward regions

AU - Hammer, Ronald P

AU - Pires, W. S.

AU - Markou, A.

AU - Koob, G. F.

PY - 1993

Y1 - 1993

N2 - The quantitative [14C]-2-deoxyglucose autoradiographic method was utilized to assess regional cerebral metabolic rate for glucose (rCMR(glc)) in rat brain during withdrawal from cocaine self-administration. RCMR(glc) was determined in 62 regions from brains of naive rats which were placed into an empty operant chamber for 12 hr continuously, and rats trained to self- administer cocaine during 3 hr training sessions and subsequently placed into the operant chamber for 12 hr continuously with or without access to cocaine. Animals placed into the chamber without access to cocaine were examined 6 hr later, while animals allowed access to the 12 hr cocaine binge were examined either 6 or 72 hr post-cocaine. Metabolic activity was reduced during withdrawal in the nucleus accumbens, olfactory tubercle, islands of Calleja region, basolateral and central amygdaloid nuclei, medial septum, piriform and cingulate cortices, rostral caudatoputamen, entopeduncular nucleus and the adjacent lateral hypothalamus, somatosensory, auditory, and motor cortices compared to the naive state. These effects were usually more severe at 72 than at 6 hr after binge exposure, with intermediate values observed in cocaine trained animals without binge exposure. The response was negatively correlated with the amount of cocaine consumed during binge exposure in the striatum, olfactory tubercle, piriform, cingulate, somatosensory, and motor cortices. Thus, the amount of cocaine consumed can affect the extent of metabolic depression after sustained drug exposure. The pattern of regional effects suggests that mesolimbic and rostral extrapyramidal dopamine terminal regions and certain of their efferent pathways are preferentially affected during cocaine withdrawal. The reduction of basal metabolic rate observed in these brain regions during cocaine withdrawal may become more severe with time despite the apparent recovery of certain behavioral-motivational responses.

AB - The quantitative [14C]-2-deoxyglucose autoradiographic method was utilized to assess regional cerebral metabolic rate for glucose (rCMR(glc)) in rat brain during withdrawal from cocaine self-administration. RCMR(glc) was determined in 62 regions from brains of naive rats which were placed into an empty operant chamber for 12 hr continuously, and rats trained to self- administer cocaine during 3 hr training sessions and subsequently placed into the operant chamber for 12 hr continuously with or without access to cocaine. Animals placed into the chamber without access to cocaine were examined 6 hr later, while animals allowed access to the 12 hr cocaine binge were examined either 6 or 72 hr post-cocaine. Metabolic activity was reduced during withdrawal in the nucleus accumbens, olfactory tubercle, islands of Calleja region, basolateral and central amygdaloid nuclei, medial septum, piriform and cingulate cortices, rostral caudatoputamen, entopeduncular nucleus and the adjacent lateral hypothalamus, somatosensory, auditory, and motor cortices compared to the naive state. These effects were usually more severe at 72 than at 6 hr after binge exposure, with intermediate values observed in cocaine trained animals without binge exposure. The response was negatively correlated with the amount of cocaine consumed during binge exposure in the striatum, olfactory tubercle, piriform, cingulate, somatosensory, and motor cortices. Thus, the amount of cocaine consumed can affect the extent of metabolic depression after sustained drug exposure. The pattern of regional effects suggests that mesolimbic and rostral extrapyramidal dopamine terminal regions and certain of their efferent pathways are preferentially affected during cocaine withdrawal. The reduction of basal metabolic rate observed in these brain regions during cocaine withdrawal may become more severe with time despite the apparent recovery of certain behavioral-motivational responses.

UR - http://www.scopus.com/inward/record.url?scp=0027323002&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027323002&partnerID=8YFLogxK

M3 - Article

C2 - 8511720

AN - SCOPUS:0027323002

VL - 14

SP - 73

EP - 80

JO - Synapse

JF - Synapse

SN - 0887-4476

IS - 1

ER -