Written language impairments in primary progressive aphasia: A reflection of damage to central semantic and phonological processes

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31 Citations (Scopus)

Abstract

Connectionist theories of language propose that written language deficits arise as a result of damage to semantic and phonological systems that also support spoken language production and comprehension, a view referred to as the "primary systems" hypothesis. The objective of the current study was to evaluate the primary systems account in a mixed group of individuals with primary progressive aphasia (PPA) by investigating the relation between measures of nonorthographic semantic and phonological processing and written language performance and by examining whether common patterns of cortical atrophy underlie impairments in spoken versus written language domains. Individuals with PPA and healthy controls were administered a language battery, including assessments of semantics, phonology, reading, and spelling. Voxel-based morphometry was used to examine the relation between gray matter volumes and language measures within brain regions previously implicated in semantic and phonological processing. In accordance with the primary systems account, our findings indicate that spoken language performance is strongly predictive of reading/spelling profile in individuals with PPA and suggest that common networks of critical left hemisphere regions support central semantic and phonological processes recruited for spoken and written language.

Original languageEnglish (US)
Pages (from-to)261-275
Number of pages15
JournalJournal of Cognitive Neuroscience
Volume24
Issue number2
DOIs
StatePublished - Feb 2012

Fingerprint

Primary Progressive Aphasia
written language
speech disorder
Semantics
spoken language
damages
Language
semantics
language
phonology
Reading
performance
brain
deficit
comprehension
Written Language
Phonological Processes
Damage
Language Impairment
Spoken Language

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Language and Linguistics
  • Linguistics and Language

Cite this

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