Xenobiotic effects on ovarian preantral follicles

Connie J. Mark-Kappeler, Patricia B Hoyer, Patrick J. Devine

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Women are born with a finite population of ovarian follicles, which are slowly depleted during their reproductive years until reproductive failure (menopause) occurs. The rate of loss of primordial follicles is determined by genetic and environmental influences, but certain toxic exposures can accelerate this process. Ionizing radiation reduces preantral follicle numbers in rodents and humans in a dose-dependent manner. Cigarette smoking is linked to menopause occurring 1-4 yr earlier than with nonsmokers, and components of smoke, polycyclic aromatic hydrocarbons, can cause follicle depletion in rodents or in ovaries in vitro. Chemotherapeutic agents, such as alkylating drugs and cisplatin, also cause loss of preantral ovarian follicles. Effects depend on dose, type, and reactivity of the drug, and the age of the individual. Evidence suggests DNA damage may underlie follicle loss induced by one common alkylating drug, cyclophosphamide. Occupational exposures have also been linked to ovarian damage. In an industrial setting, 2-bromopropane caused infertility in men and women, and it can induce ovarian follicle depletion in rats. Solvents, such as butadiene, 4-vinylcyclohexene, and their diepoxides, can also cause specific preantral follicle depletion. The mechanism(s) underlying effects of the latter compound may involve alterations in apoptosis, survival factors such as KIT/Kit Ligand, and/ or the cellular signaling that maintains primordial follicle dormancy. Estrogenic endocrine disruptors may alter follicle formation/development and impair fertility or normal development of offspring. Thus, specific exposures are known or suspected of detrimentally impacting preantral ovarian follicles, leading to early ovarian failure.

Original languageEnglish (US)
Pages (from-to)871-883
Number of pages13
JournalBiology of Reproduction
Volume85
Issue number5
DOIs
StatePublished - Nov 1 2011

Fingerprint

Ovarian Follicle
Xenobiotics
2-bromopropane
Menopause
Rodentia
Pharmaceutical Preparations
Endocrine Disruptors
Apoptosis Regulatory Proteins
Stem Cell Factor
Poisons
Polycyclic Aromatic Hydrocarbons
Occupational Exposure
Ionizing Radiation
Smoke
Cyclophosphamide
Infertility
Cisplatin
DNA Damage
Fertility
Ovary

Keywords

  • Atresia
  • Fertility
  • Follicle
  • Ovary
  • Toxicity
  • Toxicology

ASJC Scopus subject areas

  • Cell Biology

Cite this

Xenobiotic effects on ovarian preantral follicles. / Mark-Kappeler, Connie J.; Hoyer, Patricia B; Devine, Patrick J.

In: Biology of Reproduction, Vol. 85, No. 5, 01.11.2011, p. 871-883.

Research output: Contribution to journalArticle

Mark-Kappeler, Connie J. ; Hoyer, Patricia B ; Devine, Patrick J. / Xenobiotic effects on ovarian preantral follicles. In: Biology of Reproduction. 2011 ; Vol. 85, No. 5. pp. 871-883.
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