Xenobiotic transporter expression along the male genital tract

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The male genital tract plays an important role in protecting sperm by forming a distinct compartment separate from the body which limits exposure to potentially toxic substrates. Transporters along this tract can influence the distribution of xenobiotics into the male genital tract through efflux back into the blood or facilitating the accumulation of toxicants. The aim of this study was to quantitatively determine the constitutive mRNA expression of 30 xenobiotic transporters in caput and cauda regions of the epididymis, vas deferens, prostate, and seminal vesicles from adult Sprague-Dawley rats. The epididymis was found to express at least moderate levels of 18 transporters, vas deferens 15, seminal vesicles 23, and prostate 18. Constitutive expression of these xenobiotic transporters in the male genital tract may provide insight into the xenobiotics that can potentially be transported into these tissues and may provide the molecular mechanism for site specific toxicity of select agents.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalReproductive Toxicology
Volume47
DOIs
StatePublished - 2014

Fingerprint

Xenobiotics
Vas Deferens
Seminal Vesicles
Epididymis
Prostate
Poisons
Sprague Dawley Rats
Toxicity
Spermatozoa
Rats
Blood
Tissue
Messenger RNA
Substrates

Keywords

  • Drug transport
  • Male genital tract
  • Multidrug resistance proteins
  • Toxicology
  • Xenobiotics

ASJC Scopus subject areas

  • Toxicology

Cite this

Xenobiotic transporter expression along the male genital tract. / Klein, David M.; Wright, Stephen; Cherrington, Nathan J.

In: Reproductive Toxicology, Vol. 47, 2014, p. 1-8.

Research output: Contribution to journalArticle

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