Xenopus as a model system for vertebrate heart development

Andrew S. Warkman, Paul A Krieg

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

The African clawed frog, Xenopus laevis, is a valuable model system for studies of vertebrate heart development. In the following review, we describe a range of embryological and molecular methodologies that are used in Xenopus research and discuss key discoveries relating to heart development that have been made using this model system. We also discuss how the sequence of the Xenopus tropicalis genome provides a valuable tool for identification of orthologous genes and for identification of evolutionarily conserved promoter elements. Finally, both forward and reverse genetic approaches are currently being applied to Xenopus for the study of vertebrate heart development.

Original languageEnglish (US)
Pages (from-to)46-53
Number of pages8
JournalSeminars in Cell and Developmental Biology
Volume18
Issue number1
DOIs
Publication statusPublished - Feb 2007

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Keywords

  • Antisense oligonucleotides
  • Explants
  • Mis-expression
  • Promoter analysis
  • Transgenic animals

ASJC Scopus subject areas

  • Developmental Biology

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