XNkx-2.5, a Xenopus gene related to Nkx-2.5 and tinman: Evidence for a conserved role in cardiac development

Kathryn F. Tonissen, Thomas A. Drysdale, Thierry J. Lints, Richard P. Harvey, Paul A. Krieg

Research output: Contribution to journalArticlepeer-review

187 Scopus citations

Abstract

We have isolated a Xenopus homeodomain sequence, XNkx-2.5, which shows significant similarity to mouse Nkx-2.5 and to the Drosophila tinman gene product. In Drosophila, tinman is required for formation of the heart and visceral mesoderm structures. In situ hybridization studies show that XNkx-2.5 is expressed in the heart region during early Xenopus development and later is also expressed in gut tissue. The observed similarity of sequences and expression patterns suggests that the regulatory mechanisms underlying heart formation may be conserved between distant species.

Original languageEnglish (US)
Pages (from-to)325-328
Number of pages4
JournalDevelopmental biology
Volume162
Issue number1
DOIs
StatePublished - Mar 1994
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'XNkx-2.5, a Xenopus gene related to Nkx-2.5 and tinman: Evidence for a conserved role in cardiac development'. Together they form a unique fingerprint.

Cite this