Xylose disposition in humans as a function of age

Stephen L. Johnson, Michael Mayersohn, Kenneth A. Conrad

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

D‐Xylose disposition was examined in 24 healthy men between 32 and 85 years of age. Xylose was administered as a 5 gm iv infusion and as a 25 gm po solution. Serum xylose concentrations and urinary excretion of intact xylose were determined. There were statistically significant inverse relationships with age for each of the following parameters after intravenous infusion: elimination rate constant (r2 = 0.71); systemic clearance (r2 = 0.66); renal clearance (r2 = 0.66); and nonrenal clearance (r2 = 0.35). Similar inverse relationships were found after oral dosing for the elimination rate constant (r2 = 0.69) and renal clearance (r2 = 0.54). There was no significant age relationship for the apparent volume of distribution or the steady‐state volume of distribution. The percentage of the oral and intravenous dose recovered in urine up to 5 hours after dosing was significantly and inversely correlated with age. The implications of the latter finding are discussed with regard to the interpretation of the xylose tolerance test used to assess gastrointestinal absorptive capacity. Clinical Pharmacology and Therapeutics (1986) 39, 697–702; doi:

Original languageEnglish (US)
Pages (from-to)697-702
Number of pages6
JournalClinical Pharmacology & Therapeutics
Volume39
Issue number6
DOIs
StatePublished - Jun 1986

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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