Year-to-year changes in lung function in individuals with cystic fibrosis

Theodore G. Liou, Eric P. Elkin, David J. Pasta, Joan R. Jacobs, Michael W. Konstan, Wayne J Morgan, Jeffrey S. Wagener

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Background: We examined the year-to-year change in FEV1 for individuals and the overall cystic fibrosis population to better understand how individual trends may differ from population trends. Methods: We calculated individual yearly changes using the largest annual FEV1 percent predicted (FEV1%) measurement in 20,644 patients (6-45years old) included in the Epidemiologic Study of Cystic Fibrosis. We calculated yearly population changes using age-specific medians. Results: FEV1% predicted decreased 1-3 points per year for individuals, with maximal decreases in 14-15year olds. Population changes agreed with individual changes up to age 15; however after age 30, yearly population change approximated zero while individual FEV1% predicted decreases were 1-2 points per year. Conclusions: Adolescents have the greatest FEV1% predicted decreases; however, loss of FEV1 is a persistent risk in 6-45year old CF patients. Recognizing individual year-to-year changes may improve patient-specific care and may suggest new methods for measuring program quality.

Original languageEnglish (US)
Pages (from-to)250-256
Number of pages7
JournalJournal of Cystic Fibrosis
Volume9
Issue number4
DOIs
StatePublished - Jul 2010

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Cystic Fibrosis
Lung
Population
Epidemiologic Studies
Patient Care

Keywords

  • Annual trends
  • Cystic fibrosis
  • Pulmonary function

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)

Cite this

Liou, T. G., Elkin, E. P., Pasta, D. J., Jacobs, J. R., Konstan, M. W., Morgan, W. J., & Wagener, J. S. (2010). Year-to-year changes in lung function in individuals with cystic fibrosis. Journal of Cystic Fibrosis, 9(4), 250-256. https://doi.org/10.1016/j.jcf.2010.04.002

Year-to-year changes in lung function in individuals with cystic fibrosis. / Liou, Theodore G.; Elkin, Eric P.; Pasta, David J.; Jacobs, Joan R.; Konstan, Michael W.; Morgan, Wayne J; Wagener, Jeffrey S.

In: Journal of Cystic Fibrosis, Vol. 9, No. 4, 07.2010, p. 250-256.

Research output: Contribution to journalArticle

Liou, TG, Elkin, EP, Pasta, DJ, Jacobs, JR, Konstan, MW, Morgan, WJ & Wagener, JS 2010, 'Year-to-year changes in lung function in individuals with cystic fibrosis', Journal of Cystic Fibrosis, vol. 9, no. 4, pp. 250-256. https://doi.org/10.1016/j.jcf.2010.04.002
Liou, Theodore G. ; Elkin, Eric P. ; Pasta, David J. ; Jacobs, Joan R. ; Konstan, Michael W. ; Morgan, Wayne J ; Wagener, Jeffrey S. / Year-to-year changes in lung function in individuals with cystic fibrosis. In: Journal of Cystic Fibrosis. 2010 ; Vol. 9, No. 4. pp. 250-256.
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