TY - JOUR
T1 - Yeast checkpoint genes in DNA damage processing
T2 - Implications for repair and arrest
AU - Lydall, David
AU - Weinert, Ted
PY - 1995
Y1 - 1995
N2 - Yeast checkpoint control genes were found to affect processing of DNA damage as well as cell cycle arrest. An assay that measures DNA damage processing in vivo showed that the checkpoint genes RAD17, RAD24 and MEC3 activated an exonuclease that degrades DNA. The degradation is probably a direct consequence of checkpoint protein function, because RAD17 encodes a putative 3′-5′ DNA exonuclease. Another checkpoint gene, RAD9, had a different role: It inhibited the degradation by RAD17, RAD24, and MEC3. A model of how processing of DNA damage may be linked to both DNA repair and cell cycle arrest is proposed.
AB - Yeast checkpoint control genes were found to affect processing of DNA damage as well as cell cycle arrest. An assay that measures DNA damage processing in vivo showed that the checkpoint genes RAD17, RAD24 and MEC3 activated an exonuclease that degrades DNA. The degradation is probably a direct consequence of checkpoint protein function, because RAD17 encodes a putative 3′-5′ DNA exonuclease. Another checkpoint gene, RAD9, had a different role: It inhibited the degradation by RAD17, RAD24, and MEC3. A model of how processing of DNA damage may be linked to both DNA repair and cell cycle arrest is proposed.
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U2 - 10.1126/science.270.5241.1488
DO - 10.1126/science.270.5241.1488
M3 - Article
C2 - 7491494
AN - SCOPUS:0028882869
VL - 270
SP - 1488
EP - 1491
JO - Science
JF - Science
SN - 0036-8075
IS - 5241
ER -