Yes! sex matters: Sex, the brain and blood pressure

Meredith Hay, Baojian Xue, Alan Kim Johnson

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The role of the brain in hypertension between the sexes is known to be important especially with regards to the effects of circulating sex hormones. A number of different brain regions important for regulation of sympathetic outflow and blood pressure express estrogen receptors (ERα and ERβ). Estradiol, acting predominantly via the ERα, inhibits angiotensin II activation of the area postrema and subfornical organ neurons and inhibits reactive oxygen generation that is required for the development of Angiotensin II-induced neurogenic hypertension. Estradiol activation of ERβ within the paraventricular nucleus and the rostral ventral lateral medulla inhibits these neurons and inhibits angiotensin II, or aldosterone induced increases in sympathetic outflow and hypertension. Understanding the cellular and molecular mechanisms underlying ERα and ERβ actions within key brain regions regulating blood pressure will be essential for the development of "next generation" selective estrogen receptor modulators (SERMS) that can be used clinically for the treatment of neurogenic hypertension.

Original languageEnglish (US)
Article number458
JournalCurrent Hypertension Reports
Volume16
Issue number8
DOIs
StatePublished - 2014

Fingerprint

Angiotensin II
Blood Pressure
Hypertension
Brain
Estradiol
Subfornical Organ
Area Postrema
Selective Estrogen Receptor Modulators
Neurons
Paraventricular Hypothalamic Nucleus
Gonadal Steroid Hormones
Aldosterone
Estrogen Receptors
Oxygen

Keywords

  • Area postrema
  • Estradiol
  • Estrogen receptors
  • Gender
  • Hypertension
  • Nitric oxide
  • Nucleus of the solitary tract
  • Paraventricular nucleus
  • Reactive oxygen species
  • Rostral ventral lateralmedulla
  • Sex
  • Subfornical organ

ASJC Scopus subject areas

  • Internal Medicine
  • Medicine(all)

Cite this

Yes! sex matters : Sex, the brain and blood pressure. / Hay, Meredith; Xue, Baojian; Johnson, Alan Kim.

In: Current Hypertension Reports, Vol. 16, No. 8, 458, 2014.

Research output: Contribution to journalArticle

Hay, Meredith ; Xue, Baojian ; Johnson, Alan Kim. / Yes! sex matters : Sex, the brain and blood pressure. In: Current Hypertension Reports. 2014 ; Vol. 16, No. 8.
@article{2345bd2565bc4ccc9f9051db5836fd6f,
title = "Yes! sex matters: Sex, the brain and blood pressure",
abstract = "The role of the brain in hypertension between the sexes is known to be important especially with regards to the effects of circulating sex hormones. A number of different brain regions important for regulation of sympathetic outflow and blood pressure express estrogen receptors (ERα and ERβ). Estradiol, acting predominantly via the ERα, inhibits angiotensin II activation of the area postrema and subfornical organ neurons and inhibits reactive oxygen generation that is required for the development of Angiotensin II-induced neurogenic hypertension. Estradiol activation of ERβ within the paraventricular nucleus and the rostral ventral lateral medulla inhibits these neurons and inhibits angiotensin II, or aldosterone induced increases in sympathetic outflow and hypertension. Understanding the cellular and molecular mechanisms underlying ERα and ERβ actions within key brain regions regulating blood pressure will be essential for the development of {"}next generation{"} selective estrogen receptor modulators (SERMS) that can be used clinically for the treatment of neurogenic hypertension.",
keywords = "Area postrema, Estradiol, Estrogen receptors, Gender, Hypertension, Nitric oxide, Nucleus of the solitary tract, Paraventricular nucleus, Reactive oxygen species, Rostral ventral lateralmedulla, Sex, Subfornical organ",
author = "Meredith Hay and Baojian Xue and Johnson, {Alan Kim}",
year = "2014",
doi = "10.1007/s11906-014-0458-4",
language = "English (US)",
volume = "16",
journal = "Current Hypertension Reports",
issn = "1522-6417",
publisher = "Current Medicine Group",
number = "8",

}

TY - JOUR

T1 - Yes! sex matters

T2 - Sex, the brain and blood pressure

AU - Hay, Meredith

AU - Xue, Baojian

AU - Johnson, Alan Kim

PY - 2014

Y1 - 2014

N2 - The role of the brain in hypertension between the sexes is known to be important especially with regards to the effects of circulating sex hormones. A number of different brain regions important for regulation of sympathetic outflow and blood pressure express estrogen receptors (ERα and ERβ). Estradiol, acting predominantly via the ERα, inhibits angiotensin II activation of the area postrema and subfornical organ neurons and inhibits reactive oxygen generation that is required for the development of Angiotensin II-induced neurogenic hypertension. Estradiol activation of ERβ within the paraventricular nucleus and the rostral ventral lateral medulla inhibits these neurons and inhibits angiotensin II, or aldosterone induced increases in sympathetic outflow and hypertension. Understanding the cellular and molecular mechanisms underlying ERα and ERβ actions within key brain regions regulating blood pressure will be essential for the development of "next generation" selective estrogen receptor modulators (SERMS) that can be used clinically for the treatment of neurogenic hypertension.

AB - The role of the brain in hypertension between the sexes is known to be important especially with regards to the effects of circulating sex hormones. A number of different brain regions important for regulation of sympathetic outflow and blood pressure express estrogen receptors (ERα and ERβ). Estradiol, acting predominantly via the ERα, inhibits angiotensin II activation of the area postrema and subfornical organ neurons and inhibits reactive oxygen generation that is required for the development of Angiotensin II-induced neurogenic hypertension. Estradiol activation of ERβ within the paraventricular nucleus and the rostral ventral lateral medulla inhibits these neurons and inhibits angiotensin II, or aldosterone induced increases in sympathetic outflow and hypertension. Understanding the cellular and molecular mechanisms underlying ERα and ERβ actions within key brain regions regulating blood pressure will be essential for the development of "next generation" selective estrogen receptor modulators (SERMS) that can be used clinically for the treatment of neurogenic hypertension.

KW - Area postrema

KW - Estradiol

KW - Estrogen receptors

KW - Gender

KW - Hypertension

KW - Nitric oxide

KW - Nucleus of the solitary tract

KW - Paraventricular nucleus

KW - Reactive oxygen species

KW - Rostral ventral lateralmedulla

KW - Sex

KW - Subfornical organ

UR - http://www.scopus.com/inward/record.url?scp=84902051454&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84902051454&partnerID=8YFLogxK

U2 - 10.1007/s11906-014-0458-4

DO - 10.1007/s11906-014-0458-4

M3 - Article

C2 - 24929952

AN - SCOPUS:84902051454

VL - 16

JO - Current Hypertension Reports

JF - Current Hypertension Reports

SN - 1522-6417

IS - 8

M1 - 458

ER -