Yin Yang 1 and adipogenic gene network expression in longissimus muscle of beef cattle in response to nutritional management

Sonia J. Moisá, Daniel W. Shike, William T. Meteer, Duane Keisler, Dan B Faulkner, Juan J. Loor

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Among 36 differentially-expressed genes during growth in longissimus muscle (LM) of Angus steers, Yin Yang 1 (YY1) had the most relationships with other genes including some associated with adipocyte differentiation. The objective of this study was to examine the effect of nutritional management on mRNA expression of YY1 along with its targets genes PPARG, GTF2B, KAT2B, IGFBP5 and STAT5B. Longissimus from Angus and Angus×Simmental steers (7 total/treatment) on early weaning plus high-starch (EWS), normal weaning plus starch creep feeding (NWS), or normal weaning without starch creep feeding (NWN) was biopsied at 0, 96, and 240days on treatments. Results suggest that YY1 does not exert control of adipogenesis in LM, and its expression is not sensitive to weaning age. Among the YY1-related genes, EWS led to greater IGFBP5 during growing and finishing phases. Pro-adipogenic transcriptional regulation was detected in EWS due to greater PPARG and VDR at 96 and 240 d vs. 0 d. GTF2B and KAT2B expression was lower in response to NWS and EWS than NWN, and was most pronounced at 240 d. The increase in PPARG and GTF2B expression between 96 and 240 d underscored the existence of a molecular programming mechanism that was sensitive to age and dietary starch. Such response partly explains the greater carcass fat deposition observed in response to NWS.

Original languageEnglish (US)
Pages (from-to)71-83
Number of pages13
JournalGene Regulation and Systems Biology
Volume2013
Issue number7
DOIs
StatePublished - 2013
Externally publishedYes

Fingerprint

Yin-Yang
Beef
weaning
Gene Regulatory Networks
Weaning
Starch
longissimus muscle
beef cattle
starch
Muscle
muscle
Genes
creep feeding
Gene Expression
Muscles
gene
Angus
creep
Creep
genes

Keywords

  • Adipogenesis
  • Early weaning
  • Gene expression
  • Nutrition
  • Steers
  • Yin Yang 1

ASJC Scopus subject areas

  • Genetics
  • Ecology, Evolution, Behavior and Systematics
  • Computer Science Applications
  • Molecular Biology

Cite this

Yin Yang 1 and adipogenic gene network expression in longissimus muscle of beef cattle in response to nutritional management. / Moisá, Sonia J.; Shike, Daniel W.; Meteer, William T.; Keisler, Duane; Faulkner, Dan B; Loor, Juan J.

In: Gene Regulation and Systems Biology, Vol. 2013, No. 7, 2013, p. 71-83.

Research output: Contribution to journalArticle

Moisá, Sonia J. ; Shike, Daniel W. ; Meteer, William T. ; Keisler, Duane ; Faulkner, Dan B ; Loor, Juan J. / Yin Yang 1 and adipogenic gene network expression in longissimus muscle of beef cattle in response to nutritional management. In: Gene Regulation and Systems Biology. 2013 ; Vol. 2013, No. 7. pp. 71-83.
@article{1aa9a7a6916b4bb9b06658af421ac1c6,
title = "Yin Yang 1 and adipogenic gene network expression in longissimus muscle of beef cattle in response to nutritional management",
abstract = "Among 36 differentially-expressed genes during growth in longissimus muscle (LM) of Angus steers, Yin Yang 1 (YY1) had the most relationships with other genes including some associated with adipocyte differentiation. The objective of this study was to examine the effect of nutritional management on mRNA expression of YY1 along with its targets genes PPARG, GTF2B, KAT2B, IGFBP5 and STAT5B. Longissimus from Angus and Angus×Simmental steers (7 total/treatment) on early weaning plus high-starch (EWS), normal weaning plus starch creep feeding (NWS), or normal weaning without starch creep feeding (NWN) was biopsied at 0, 96, and 240days on treatments. Results suggest that YY1 does not exert control of adipogenesis in LM, and its expression is not sensitive to weaning age. Among the YY1-related genes, EWS led to greater IGFBP5 during growing and finishing phases. Pro-adipogenic transcriptional regulation was detected in EWS due to greater PPARG and VDR at 96 and 240 d vs. 0 d. GTF2B and KAT2B expression was lower in response to NWS and EWS than NWN, and was most pronounced at 240 d. The increase in PPARG and GTF2B expression between 96 and 240 d underscored the existence of a molecular programming mechanism that was sensitive to age and dietary starch. Such response partly explains the greater carcass fat deposition observed in response to NWS.",
keywords = "Adipogenesis, Early weaning, Gene expression, Nutrition, Steers, Yin Yang 1",
author = "Mois{\'a}, {Sonia J.} and Shike, {Daniel W.} and Meteer, {William T.} and Duane Keisler and Faulkner, {Dan B} and Loor, {Juan J.}",
year = "2013",
doi = "10.4137/GRSB.S11783",
language = "English (US)",
volume = "2013",
pages = "71--83",
journal = "Gene Regulation and Systems Biology",
issn = "1177-6250",
publisher = "Libertas Academica Ltd.",
number = "7",

}

TY - JOUR

T1 - Yin Yang 1 and adipogenic gene network expression in longissimus muscle of beef cattle in response to nutritional management

AU - Moisá, Sonia J.

AU - Shike, Daniel W.

AU - Meteer, William T.

AU - Keisler, Duane

AU - Faulkner, Dan B

AU - Loor, Juan J.

PY - 2013

Y1 - 2013

N2 - Among 36 differentially-expressed genes during growth in longissimus muscle (LM) of Angus steers, Yin Yang 1 (YY1) had the most relationships with other genes including some associated with adipocyte differentiation. The objective of this study was to examine the effect of nutritional management on mRNA expression of YY1 along with its targets genes PPARG, GTF2B, KAT2B, IGFBP5 and STAT5B. Longissimus from Angus and Angus×Simmental steers (7 total/treatment) on early weaning plus high-starch (EWS), normal weaning plus starch creep feeding (NWS), or normal weaning without starch creep feeding (NWN) was biopsied at 0, 96, and 240days on treatments. Results suggest that YY1 does not exert control of adipogenesis in LM, and its expression is not sensitive to weaning age. Among the YY1-related genes, EWS led to greater IGFBP5 during growing and finishing phases. Pro-adipogenic transcriptional regulation was detected in EWS due to greater PPARG and VDR at 96 and 240 d vs. 0 d. GTF2B and KAT2B expression was lower in response to NWS and EWS than NWN, and was most pronounced at 240 d. The increase in PPARG and GTF2B expression between 96 and 240 d underscored the existence of a molecular programming mechanism that was sensitive to age and dietary starch. Such response partly explains the greater carcass fat deposition observed in response to NWS.

AB - Among 36 differentially-expressed genes during growth in longissimus muscle (LM) of Angus steers, Yin Yang 1 (YY1) had the most relationships with other genes including some associated with adipocyte differentiation. The objective of this study was to examine the effect of nutritional management on mRNA expression of YY1 along with its targets genes PPARG, GTF2B, KAT2B, IGFBP5 and STAT5B. Longissimus from Angus and Angus×Simmental steers (7 total/treatment) on early weaning plus high-starch (EWS), normal weaning plus starch creep feeding (NWS), or normal weaning without starch creep feeding (NWN) was biopsied at 0, 96, and 240days on treatments. Results suggest that YY1 does not exert control of adipogenesis in LM, and its expression is not sensitive to weaning age. Among the YY1-related genes, EWS led to greater IGFBP5 during growing and finishing phases. Pro-adipogenic transcriptional regulation was detected in EWS due to greater PPARG and VDR at 96 and 240 d vs. 0 d. GTF2B and KAT2B expression was lower in response to NWS and EWS than NWN, and was most pronounced at 240 d. The increase in PPARG and GTF2B expression between 96 and 240 d underscored the existence of a molecular programming mechanism that was sensitive to age and dietary starch. Such response partly explains the greater carcass fat deposition observed in response to NWS.

KW - Adipogenesis

KW - Early weaning

KW - Gene expression

KW - Nutrition

KW - Steers

KW - Yin Yang 1

UR - http://www.scopus.com/inward/record.url?scp=84876464064&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84876464064&partnerID=8YFLogxK

U2 - 10.4137/GRSB.S11783

DO - 10.4137/GRSB.S11783

M3 - Article

C2 - 23700364

AN - SCOPUS:84876464064

VL - 2013

SP - 71

EP - 83

JO - Gene Regulation and Systems Biology

JF - Gene Regulation and Systems Biology

SN - 1177-6250

IS - 7

ER -