Ytterbium-DTPA: A potential intravascular contrast agent

Evan Unger, Fernando Gutierrez

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Ytterbium-DTPA was evaluated as a potential intravascular contrast agent. Ytterbium-DTPA was synthesized from ytterbium oxide and diethylene triamine penta-acetic acid (DTPA). CT scans of increasing concentrations of ytterbium and iodine showed that at 125 kVp, ytterbium was denser than an equal concentration of iodine. The LD50 of intravenous ytterbium-DTPA was 10 mM/kg (1.73 g ytterbium/kg) in rats. In enhanced CT scans and pulmonary angiography in dogs, ytterbium was visibly denser than iodine, and CT Hounsfield units showed greater enhancement of the aorta and inferior vena cava with ytterbium. The animals showed no sign of acute or delayed toxicity. Ytterbium-DTPA deserves further evaluation as a contrast agent for high kVp techniques.

Original languageEnglish (US)
Pages (from-to)802-807
Number of pages6
JournalInvestigative Radiology
Volume21
Issue number10
DOIs
StatePublished - Oct 1986
Externally publishedYes

Keywords

  • Contrast agent
  • Heavy metal chelate
  • Lanthanide elements
  • Ytterbium-DTPA

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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