Zinagrandinolides A-C, cytotoxic δ-elemanolide-type sesquiterpene lactones from Zinnia grandiflora

Bharat P. Bashyal, Steven P. McLaughlin, Leslie Gunatilaka

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Three new δ-elemanolide-type sesquiterpene lactones, zinagrandinolides A-C (1-3), and the known δ-elemanolide 4 have been isolated by a bioassay-guided fractionation of a cytotoxic hexane extract of the aerial parts of Zinnia grandiflora. The structures of 1-3 were determined on the basis of high-resolution mass and NMR data. All compounds exhibited strong cytotoxicity against the cancer cell lines NCI-H460, MCF-7, SF-268, and MIA Pa Ca-2 and the normal human fibroblast cell type WI-38, but none showed significant selectivity.

Original languageEnglish (US)
Pages (from-to)1820-1822
Number of pages3
JournalJournal of Natural Products
Volume69
Issue number12
DOIs
StatePublished - Dec 2006

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Zinnia
Sesquiterpenes
sesquiterpenoid lactones
Hexanes
Lactones
Biological Assay
hexane
fibroblasts
aerial parts
cytotoxicity
fractionation
bioassays
Fibroblasts
Cells
cell lines
Cell Line
Bioassay
extracts
Cytotoxicity
Fractionation

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Zinagrandinolides A-C, cytotoxic δ-elemanolide-type sesquiterpene lactones from Zinnia grandiflora. / Bashyal, Bharat P.; McLaughlin, Steven P.; Gunatilaka, Leslie.

In: Journal of Natural Products, Vol. 69, No. 12, 12.2006, p. 1820-1822.

Research output: Contribution to journalArticle

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