Zinagrandinolides A-C, cytotoxic δ-elemanolide-type sesquiterpene lactones from Zinnia grandiflora

Bharat P. Bashyal, Steven P. McLaughlin, A. A.Leslie Gunatilaka

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Three new δ-elemanolide-type sesquiterpene lactones, zinagrandinolides A-C (1-3), and the known δ-elemanolide 4 have been isolated by a bioassay-guided fractionation of a cytotoxic hexane extract of the aerial parts of Zinnia grandiflora. The structures of 1-3 were determined on the basis of high-resolution mass and NMR data. All compounds exhibited strong cytotoxicity against the cancer cell lines NCI-H460, MCF-7, SF-268, and MIA Pa Ca-2 and the normal human fibroblast cell type WI-38, but none showed significant selectivity.

Original languageEnglish (US)
Pages (from-to)1820-1822
Number of pages3
JournalJournal Of Natural Products
Volume69
Issue number12
DOIs
StatePublished - Dec 1 2006

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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