Zinc inhibits hedgehog autoprocessing: Linking zinc deficiency with hedgehog activation

Jian Xie, Timothy Owen, Ke Xia, Ajay Vikram Singh, Emiley Tou, Lingyun Li, Brigitte Arduini, Hongmin Li, Leo Q. Wan, Brian Callahan, Chunyu Wang

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Background: In many types of cancers zinc deficiency and overproduction of Hedgehog (Hh) ligand co-exist. Results: Zinc binds to the active site of the Hedgehog-intein (Hint) domain and inhibits Hh ligand production both in vitro and in cell culture. Conclusion: Zinc influences the Hh autoprocessing. Significance: This study uncovers a novel mechanistic link between zinc and the Hh signaling pathway.

Original languageEnglish (US)
Pages (from-to)11591-11600
Number of pages10
JournalJournal of Biological Chemistry
Volume290
Issue number18
DOIs
StatePublished - May 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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